470478-90-1

Basic information

• Product Name: 4-(4-TERT-BUTOXYCARBONYLPIPERAZINYL)PHENYLBORONIC ACID, PINACOL ESTER
• Synonyms: TERT-BUTYL 4-[4-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)PHENYL]TETRAHYDRO-1(2H)-PYRAZINECARBOXYLATE;4-(4-TERT-BUTOXYCARBONYLPIPERAZINYL)PHENYLBORONIC ACID, PINACOL ESTER;4-[4-(TERT-BUTOXYCARBONYL)PIPERAZIN-1-YL]PHENYLBORONIC ACID PINACOL ESTER;4(N-TERT-BUTOXYCARBONYLPIPERAZINE)BENZENEBORONIC ACID PINACOL ESTER;4-Piperazin-1-ylbenzeneboronic acid pinacol ester, N4-BOC protected;Tert-butyl4-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)tetrahydro-1(2H)-pyrazinecarboxylate;4-[4-(N-Boc)piperazin-1-yl]phenylboronic acid pinacol ester;t-butyl 4-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]piperazinecarboxylate
• CAS NO: 470478-90-1
• Molecular Formula: C₂₁H₃₃BN₂O₄
• Molecular Weight: 388.31
• Product Categories: Aryl;Boronic ester;Organoborons
• Mol File: 470478-90-1.mol
• Article Data: 15

Chemical Properties

• Melting Point: 157 °C
• Boiling Point: 501.7 °C at 760 mmHg
• Flash Point: 257.2 °C
• Appearance: /
• Density: 1.11
• Vapor Pressure: 3.4E-10mmHg at 25°C
• Refractive Index: 1.536
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature
• PKA: 3.06±0.10(Predicted)
• CAS DataBase Reference: 4-(4-TERT-BUTOXYCARBONYLPIPERAZINYL)PHENYLBORONIC ACID, PINACOL ESTER(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(4-TERT-BUTOXYCARBONYLPIPERAZINYL)PHENYLBORONIC ACID, PINACOL ESTER(470478-90-1)
• EPA Substance Registry System: 4-(4-TERT-BUTOXYCARBONYLPIPERAZINYL)PHENYLBORONIC ACID, PINACOL ESTER(470478-90-1)

Safety Data

• Statements: 36/37/38
• Safety Statements: 26-36
• Hazardous Substances Data: 470478-90-1(Hazardous Substances Data)

Usage

Description

4-(4-TERT-BUTOXYCARBONYLPIPERAZINYL)PHENYLBORONIC ACID, PINACOL ESTER is a chemical compound that serves as a key intermediate in the synthesis of various radiolabeled compounds. It is characterized by its ability to form stable boronate esters, which are essential for the development of radiopharmaceuticals.

Uses

Used in Pharmaceutical Industry:
4-(4-TERT-BUTOXYCARBONYLPIPERAZINYL)PHENYLBORONIC ACID, PINACOL ESTER is used as a reactant for the preparation of 211Atand 125I-radiolabeled compounds. These radiolabeled compounds are crucial in the development of targeted radiopharmaceuticals for diagnostic and therapeutic applications in nuclear medicine. 4-(4-TERT-BUTOXYCARBONYLPIPERAZINYL)PHENYLBORONIC ACID, PINACOL ESTER's ability to form stable boronate esters allows for the efficient incorporation of radioactive isotopes, enhancing the effectiveness of these radiopharmaceuticals in detecting and treating various diseases, including cancer.
Used in Radiochemistry Research:
In the field of radiochemistry, 4-(4-TERT-BUTOXYCARBONYLPIPERAZINYL)PHENYLBORONIC ACID, PINACOL ESTER is used as a valuable building block for the synthesis of novel radiotracers. These radiotracers are essential tools in understanding biological processes and developing new therapeutic strategies. 4-(4-TERT-BUTOXYCARBONYLPIPERAZINYL)PHENYLBORONIC ACID, PINACOL ESTER's unique chemical properties enable the design and synthesis of innovative radiotracers with improved targeting and imaging capabilities.
Used in Cancer Research:
4-(4-TERT-BUTOXYCARBONYLPIPERAZINYL)PHENYLBORONIC ACID, PINACOL ESTER plays a significant role in cancer research, particularly in the development of targeted alpha therapy (TAT) agents. These agents utilize alpha-emitting radionuclides, such as 211At, to deliver highly cytotoxic radiation directly to cancer cells, minimizing damage to surrounding healthy tissue. 4-(4-TERT-BUTOXYCARBONYLPIPERAZINYL)PHENYLBORONIC ACID, PINACOL ESTER's ability to form stable boronate esters with radionuclides makes it an essential component in the design and synthesis of TAT agents.

InChI:InChI=1/C21H33BN2O4/c1-19(2,3)26-18(25)24-14-12-23(13-15-24)17-10-8-16(9-11-17)22-27-20(4,5)21(6,7)28-22/h8-11H,12-15H2,1-7H3

Upstream product

• 106-37-6 1.4-dibromobenzene 
• 57260-71-6 1-t-Butoxycarbonylpiperazine 
• 589-87-7 1,4-bromoiodobenzene 
• 104-95-0 (4-bromophenyl)thioanisole 
• 909418-89-9 tert-butyl 4-(4-(methylthio)phenyl)piperazine-1-carboxylate 
• 73183-34-3 bis(pinacol)diborane 
• 66698-28-0 1-(4-bromophenyl)piperazine 
• 24424-99-5 di-tert-butyl dicarbonate 
• 352437-09-3 tert-butyl 4-(4-bromophenyl)piperazine-1-carboxylate 
• 374930-88-8 tert-butyl 4-(5-bromopyrimidin-2-yl)piperazine-1-carboxylate 

Downstream Products

• 1062368-25-5 C₂₁H₂₅N₅O₂ 
• 1062368-36-8 methyl 6-(4-piperazin-1-ylphenyl)pyrazolo[1,5-a]pyridine-3-carboxylate 
• 1201789-89-0 2-methyl-2-propyl 4-{4-[6-(pyrid-3-yl)-9H-pyrrolo[2,3-b:5,4-c']dipyrid-3-yl]phenyl}piperazine-1-carboxylate 
• 1379522-35-6 tert-butyl 4-(4-{[4-(methylsulfonyl)benzyl]oxy}phenyl)piperazine-1-carboxylate 
• 158985-25-2 tert-butyl 4-(4-hydroxyphenyl)piperazine-1-carboxylate 
• 1374342-25-2 ethyl 1-{6-[4-methyl-4'-(piperazin-1-yl)biphenyl-2-yl]pyridin-2-yl}-5-(trifluoromethyl)-1H-pyrazole-4-carboxylate 
• 1374339-40-8 1-(6-{4'-[4-(cyclopropylsulfonyl)piperazin-1-yl]-4-methylbiphenyl-2-yl}pyridin-2-yl)-5-(trifluoromethyl)-1H-pyrazole-4-carboxylic acid 
• 1374339-41-9 1-{6-[4'-(4-cyclopropylpiperazin-1-yl)-4-methylbiphenyl-2-yl]pyridin-2-yl}-5-(trifluoromethyl)-1H-pyrazole-4-carboxylic acid 
• 1374339-42-0 1-[6-(4'-{4-[(3,3-difluorocyclobutyl)carbonyl]piperazin-1-yl}-4-methylbiphenyl-2-yl)pyridin-2-yl]-5-(trifluoromethyl)-1H-pyrazole-4-carboxylic acid 
• 1374339-43-1 1-(6-{4'-[4-(cyclopropylmethyl)piperazin-1-yl]-4-methylbiphenyl-2-yl}pyridin-2-yl)-5-(trifluoromethyl)-1H-pyrazole-4-carboxylic acid 
• 1374342-26-3 C₃₄H₃₆F₃N₅O₄ 

Relevant articles and documents

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