106247-35-2 Usage
Description
GAMMA-METHYL-L-LEUCINE, also known as 2-Amino-4,4-dimethylpentanoic Acid, is an unnatural amino acid that has gained significant attention in the field of biological research. It is characterized by its unique structure, which allows it to interact with various biological systems and exhibit specific properties that make it a valuable compound for in vitro studies.
Uses
Used in Pharmaceutical Industry:
GAMMA-METHYL-L-LEUCINE is used as a research compound for the development of highly modified macrocyclic peptide analogs. These analogs act as tight-binding inhibitors of thrombin, a key enzyme involved in the coagulation cascade. By inhibiting thrombin, these peptide analogs have the potential to be used in the treatment of various conditions related to blood clotting, such as deep vein thrombosis, pulmonary embolism, and acute coronary syndrome.
Used in Biomedical Research:
In the field of biomedical research, GAMMA-METHYL-L-LEUCINE is utilized as a valuable tool for studying the structure and function of proteins and enzymes, particularly those involved in the coagulation process. Its unique properties enable researchers to gain a deeper understanding of the molecular mechanisms underlying blood clotting and to develop novel therapeutic strategies for related diseases.
Used in Drug Design and Development:
GAMMA-METHYL-L-LEUCINE plays a crucial role in the design and development of new drugs targeting thrombin and other related enzymes. Its incorporation into peptide analogs and other drug candidates can lead to the creation of more potent and selective inhibitors, which can be used to treat a variety of clotting disorders and other conditions associated with abnormal blood clotting.
Check Digit Verification of cas no
The CAS Registry Mumber 106247-35-2 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,0,6,2,4 and 7 respectively; the second part has 2 digits, 3 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 106247-35:
(8*1)+(7*0)+(6*6)+(5*2)+(4*4)+(3*7)+(2*3)+(1*5)=102
102 % 10 = 2
So 106247-35-2 is a valid CAS Registry Number.
106247-35-2Relevant articles and documents
PEPTIDES CONTAINING A NEOPENTYLGLYCINE RESIDUE
Pospisek, Jan,Blaha, Karel
, p. 514 - 521 (2007/10/02)
Neopentylglycine (III, 2-amino-4,4-dimethylpentanoic acid) was synthesized in both enantiomeric forms.Using the conventional methods of peptide synthesis, L-prolyl-L-neopentylglycylglycine amide (VII), the diastereomeric cyclodipeptides cyclo(L-neopentylglycyl-L-prolyl) (IXa) and cyclo(D-neopentylglycyl-L-prolyl) (IXb) and also N-acetyl-L-neopentylglycine methylamide (X) were prepared as models for further studies on physical properties and conformation of peptides.
