106356-54-1Relevant articles and documents
Asymmetric rearrangement of racemic epoxides catalyzed by chiral Br?nsted acids
Zhuang, Minyang,Du, Haifeng
, p. 1460 - 1462 (2013)
This paper describes a chiral Br?nsted acid catalyzed asymmetric 1,2-rearrangement of racemic epoxides via a hydrogen-shift process for the synthesis of chiral aldehydes, and, followed by a reduction, a variety of optically active alcohols can be furnished in moderate yields with up to 50% ee. Especially, a facile one-pot synthesis of chiral alcohols directly from simple alkenes by a sequential epoxidation, rearrangement, and reduction has also been realized.
Highly enantioselective hydroformylation of aryl alkenes with diazaphospholane ligands
Watkins, Avery L.,Hashiguchi, Brian G.,Landis, Clark R.
scheme or table, p. 4553 - 4556 (2009/05/13)
(Chemical Equation Presented) Asymmetric, rhodium-catalyzed hydroformylation of terminal and internal aryl alkenes with diazaphospholane ligands is reported. Under partially optimized reaction conditions, high enantioselectivity (>90% ee) and regioselectivities (up to 65:1 α:β) are obtained for most substrates. For terminal alkenes, both enantioselectivity and regioselectivity are proportional to the carbon monoxide partial pressure, but independent of hydrogen pressure. Hydroformylation of para-substituted styrene derivatives gives the highest regioselectivity for substrates bearing electron-withdrawing substituents. A Hammett analysis produces a positive linear correlation for regioselectivity.
Enantioselective addition of amines to ketenes catalyzed by a planar-chiral derivative of PPY: possible intervention of chiral Bronsted-acid catalysis.
Hodous, Brian L,Fu, Gregory C
, p. 10006 - 10007 (2007/10/03)
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