1064196-07-1

Basic information

• Product Name: N-phthalimide-3,4-dihydroxy-L-phenylalanine methyl ester
• Synonyms: N-phthalimide-3,4-dihydroxy-L-phenylalanine methyl ester
• CAS NO: 1064196-07-1
• Molecular Weight: 341.32
• Mol File: 1064196-07-1.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: N-phthalimide-3,4-dihydroxy-L-phenylalanine methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: N-phthalimide-3,4-dihydroxy-L-phenylalanine methyl ester(1064196-07-1)
• EPA Substance Registry System: N-phthalimide-3,4-dihydroxy-L-phenylalanine methyl ester(1064196-07-1)

Safety Data

• Hazardous Substances Data: 1064196-07-1(Hazardous Substances Data)

Upstream product

• 67-56-1 methanol 
• 59-92-7 levodopa 
• 22509-74-6 N-ethoxycarbonylphthalimide 

Downstream Products

• 852288-18-7 (2S)-3-(2,2-dimethyl-1,3-benzodioxol-5-yl)-2-(9H-fluoren-9-ylmethoxycarbonylamino)propanoic acid 

Relevant articles and documents

Convenient synthesis of diaryliodonium salts for the production of [18F]F-DOPA

[18F]F-DOPA is an important radiotracer that is used in the diagnosis of Parkinson's disease and neuroendocrine tumours. We describe a simple synthesis for a number of diaryliodonium salt precursors that are suitable for the production of [18F]F-DOPA through reaction with no carrier added (n.c.a.) nucleophilic [18F]fluoride. The simple procedure gives bench-stable, complex iodonium precursors in good yields without the need for laborious anhydrous conditions. Further alteration to the precursor counterion can be readily achieved for a range of halides and pseudo halides by a simple modification of the workup. Preliminary "hot" and "cold" fluorination results show the suitability of the compounds for the production of [18F]F-DOPA.

Method of synthesizing acetonide-protected catechol-containing compounds and intermediates produced therein

The inventors disclose here a novel, facile approach to the synthesis of acetonide-protected catechol-containing compounds having at least one amine group. In specific embodiments, the invention provides novel methods of synthesizing 3,4-dihydroxyphenylalanine (H-DOPA(acetonide)-OH (6)), Fmoc-protected H-DOPA(acetonide)-OH (Fmoc-DOPA(acetonide)-OH (7)), Fmoc-protected dopamine (Fmoc-dopamine(acetonide) (10)), TFA-protected dopamine (TFA-dopamine(acetonide) (13)) and acetonide-protected 4-(2-aminoethyl)benzene-1,2-diol (acetonide-protected dopamine (14)).