106549-54-6

Basic information

• Product Name: 2(3H)-Furanone, dihydro-3-methylene-5-(2-phenylethenyl)-
• CAS NO: 106549-54-6
• Molecular Formula: C13H12O2
• Molecular Weight: 200.237
• Mol File: 106549-54-6.mol
• Article Data: 8

Chemical Properties

• CAS DataBase Reference: 2(3H)-Furanone, dihydro-3-methylene-5-(2-phenylethenyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: 2(3H)-Furanone, dihydro-3-methylene-5-(2-phenylethenyl)-(106549-54-6)
• EPA Substance Registry System: 2(3H)-Furanone, dihydro-3-methylene-5-(2-phenylethenyl)-(106549-54-6)

Safety Data

• Hazardous Substances Data: 106549-54-6(Hazardous Substances Data)

Upstream product

• 104-55-2 3-phenyl-propenal 
• 14371-10-9 (E)-3-phenylpropenal 
• 4224-69-5 methyl 2-(bromomethyl)propenoate 
• 133285-88-8 ethyl 2-(methoxycarbonyloxymethyl)acrylate 
• 10029-04-6 ethyl 2-(hydroxymethyl)acrylate 
• 17435-72-2 ethyl 2-bromomethyl-2-propenoate 
• 72707-66-5 2-(bromomethyl)acrylic acid 

Relevant articles and documents

A new approach for the synthesis of α-methylene-γ-butyrolactones from α-bromomethylacrylic acids (or esters)

This paper reports that a new approach for the synthesis of α-methylene-γ-butyrolactones from the reaction of α-bromomethyl acrylic acid (or ester), powdered tin and carbonyl compounds in one pot with excellent to good yields.

A New Synthesis of γ-Substituted α-Methylene-γ-butyrolactones (2-Methylene-4-alkanolides) using Catalysis by SnCl2/Amberlyst 15

Reaction of α-bromomethylacrylic acid with aldehydes or ketones in an SnCl2/amberlyst 15/THF/H2O system affords 2-methylene-4-alkanolides in mostly good yields.

Preparation method and applications of parthenolide analogues

The invention relates to a preparation method and applications of parthenolide analogues, and belongs to the field of organic synthesis. On the basis of reserving the main active group alpha-methylene-gamma-lactone and epoxide structure of parthenolide, series of compounds are designed by changing its framework, and its in-vitro antitumor activity is tested. Series of parthenolide analogues having biological activity are synthesized by a simple method, wherein two compounds are nontoxic to normal cells.