1072088-64-2

Basic information

• Product Name: (2S)-1-benzyl-2-methylpiperidin-3-one
• Synonyms: (2S)-1-benzyl-2-methylpiperidin-3-one
• CAS NO: 1072088-64-2
• Molecular Weight: 203.284
• Mol File: 1072088-64-2.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: (2S)-1-benzyl-2-methylpiperidin-3-one(CAS DataBase Reference)
• NIST Chemistry Reference: (2S)-1-benzyl-2-methylpiperidin-3-one(1072088-64-2)
• EPA Substance Registry System: (2S)-1-benzyl-2-methylpiperidin-3-one(1072088-64-2)

Safety Data

• Hazardous Substances Data: 1072088-64-2(Hazardous Substances Data)

Upstream product

• 1462379-99-2 C₁₃H₂₁NO₂ 
• 1462379-52-7 (2S)-2-(benzyl(benzyloxycarbonyl)amino)-6-hydroxy-3-hexanone 
• 100-52-7 benzaldehyde 
• 109468-23-7 (2S)-N-benzyloxycarbonyl-N-benzyl-2-aminopropanoic acid 
• 7585-47-9 N-benzyl-(S)-alanine 
• 1462379-42-5 (2S)-N-methyl-N-methoxy-2-(benzyl(benzyloxycarbonyl)amino)propanoic amide 
• 1000414-75-4 (2S)-1-benzyl-2-methyl-1,6-dihydropyridin-3(2H)-one 

Relevant articles and documents

Concise, stereodivergent and highly stereoselective synthesis of cis-and trans-2-substituted 3-hydroxypiperidines-development of a phosphite-driven cyclodehydration

A concise (5 to 6 steps), stereodivergent, highly diastereoselective (dr up to >19:1 for both stereoisomers) and scalable synthesis (up to 14 g) of cis- and trans-2-substituted 3-piperidinols, a core motif in numerous bioactive compounds, is presented. This sequence allowed an efficient synthesis of the NK-1 inhibitor L-733,060 in 8 steps. Additionally, a cyclodehydration-realizing simple triethylphosphite as a substitute for triphenylphosphine is developed. Here the stoichiometric oxidized P(V)-byproduct (triethylphosphate) is easily removed during the work up through saponification overcoming separation difficulties usually associated to triphenylphosphine oxide.