109468-23-7

Basic information

• Product Name: L-Alanine, N-[(phenylmethoxy)carbonyl]-N-(phenylmethyl)-
• CAS NO: 109468-23-7
• Molecular Formula: C18H19NO4
• Molecular Weight: 313.353
• Mol File: 109468-23-7.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: L-Alanine, N-[(phenylmethoxy)carbonyl]-N-(phenylmethyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: L-Alanine, N-[(phenylmethoxy)carbonyl]-N-(phenylmethyl)-(109468-23-7)
• EPA Substance Registry System: L-Alanine, N-[(phenylmethoxy)carbonyl]-N-(phenylmethyl)-(109468-23-7)

Safety Data

• Hazardous Substances Data: 109468-23-7(Hazardous Substances Data)

Upstream product

• 124-38-9 carbon dioxide 
• 123933-96-0 Benzyl-(1-tributylstannanyl-ethyl)-carbamic acid benzyl ester 
• 100-52-7 benzaldehyde 
• 7585-47-9 N-benzyl-(S)-alanine 
• 501-53-1 benzyl chloroformate 

Downstream Products

• 1108198-70-4 (3S)-N-benzyloxycarbonyl-3-benzylamino-1-diazobutan-2-one 
• 1462379-99-2 C₁₃H₂₁NO₂ 
• 1072088-64-2 (2S)-1-benzyl-2-methylpiperidin-3-one 
• 1462379-90-3 (2S,3R)-1-benzyl-2-methyl-3-piperidinol 
• 192937-90-9 Benzyl-[(S)-1-((R)-2-hydroxy-1-phenyl-ethylcarbamoyl)-ethyl]-carbamic acid benzyl ester 
• 1026246-10-5 C₂₃H₂₇NO₆ 

Relevant articles and documents

Concise, stereodivergent and highly stereoselective synthesis of cis-and trans-2-substituted 3-hydroxypiperidines-development of a phosphite-driven cyclodehydration

A concise (5 to 6 steps), stereodivergent, highly diastereoselective (dr up to >19:1 for both stereoisomers) and scalable synthesis (up to 14 g) of cis- and trans-2-substituted 3-piperidinols, a core motif in numerous bioactive compounds, is presented. This sequence allowed an efficient synthesis of the NK-1 inhibitor L-733,060 in 8 steps. Additionally, a cyclodehydration-realizing simple triethylphosphite as a substitute for triphenylphosphine is developed. Here the stoichiometric oxidized P(V)-byproduct (triethylphosphate) is easily removed during the work up through saponification overcoming separation difficulties usually associated to triphenylphosphine oxide.

Enantiomerically Enriched t-BOC-Protected α-Aminoorganolithiums: Preparation and Configurational Stability

Enantiomerically enriched t-BOC-protected α-aminoorganolithiums, generated by Sn-Li exchange, are configurationally stable at -95 deg C and may be trapped with complete retention of configuration.