107437-25-2Relevant articles and documents
9,11-Epoxy-9-homo-14-thiaprost-5-enoic Acid Derivatives: Potent Thromboxane A2 Antagonists
Hall, Steven E.,Han, Wen-Ching,Harris, Don N.,Hedberg, Anders,Ogletree, Martin L.
, p. 974 - 984 (2007/10/02)
A novel bicyclic prostaglandine analogue, (1S)--7--7-oxabicyclohept-2-yl>-5-heptenoic acid ((-)10), and its congeners were found to be potent antagonists at the TxA2 receptor.Compound (-)-10 was the only stereo
7-Oxabicycloheptane substituted thio prostaglandin analogs and their use in the treatment of thrombolytic disease
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, (2008/06/13)
7-Oxabicycloheptane substituted thio prostaglandin analogs are provided having the structural formula STR1 wherein R is hydrogen, lower alkyl or alkali metal, R1 is lower alkyl, arylalkyl, aryl, cycloalkyl or cycloalkylalkyl, X is O, S or NH, A is --CH=CH-- or --(CH2)2, p is 0 to 4, n is 1 to 4, n' is 0 to 2, q is 1 to 4 and m is 0 to 8, and including all stereoisomers thereof. The compounds are cardiovascular agents useful, for example, in the treatment of thrombolytic disease; and are antiinflammatory agents useful, for example, in the treatment of rheumatoid arthritis.