110106-62-2

Basic information

• Product Name: (Z)-7-((1S,2R,3R,4R)-3-{[2-(4-Methoxy-phenylamino)-acetylamino]-methyl}-7-oxa-bicyclo[2.2.1]hept-2-yl)-hept-5-enoic acid
• CAS NO: 110106-62-2
• Molecular Weight: 416.517
• Mol File: 110106-62-2.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (Z)-7-((1S,2R,3R,4R)-3-{[2-(4-Methoxy-phenylamino)-acetylamino]-methyl}-7-oxa-bicyclo[2.2.1]hept-2-yl)-hept-5-enoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: (Z)-7-((1S,2R,3R,4R)-3-{[2-(4-Methoxy-phenylamino)-acetylamino]-methyl}-7-oxa-bicyclo[2.2.1]hept-2-yl)-hept-5-enoic acid(110106-62-2)
• EPA Substance Registry System: (Z)-7-((1S,2R,3R,4R)-3-{[2-(4-Methoxy-phenylamino)-acetylamino]-methyl}-7-oxa-bicyclo[2.2.1]hept-2-yl)-hept-5-enoic acid(110106-62-2)

Safety Data

• Hazardous Substances Data: 110106-62-2(Hazardous Substances Data)

Upstream product

• 107437-26-3 methyl <1S-<1α,2α(Z),3α,4α>>-7-<3-(aminomethyl)-7-oxabicyclo<2.2.1>hept-2-yl>-5-heptenoate 
• 22094-69-5 N-(4-methoxyphenyl)glycine 
• 110106-61-1 (Z)-7-((1S,2R,3R,4R)-3-{[2-(4-Methoxy-phenylamino)-acetylamino]-methyl}-7-oxa-bicyclo[2.2.1]hept-2-yl)-hept-5-enoic acid methyl ester 
• 107437-25-2 methyl <1S-<1α,2α(Z),3α,4α>>-7-<3-<(tosyloxy)methyl>-7-oxabicyclo<2.2.1>hept-2-yl>-5-heptanoate 
• 107437-27-4 (Z)-7-[(1S,2R,3R,4R)-3-(1,3-Dioxo-1,3-dihydro-isoindol-2-ylmethyl)-7-oxa-bicyclo[2.2.1]hept-2-yl]-hept-5-enoic acid methyl ester 

Relevant articles and documents

7-Oxabicycloheptyl Carboxylic Acids as Thromboxane A2 Antagonists: Aza ω-Chain Analogues

A novel bicyclic prostaglandin analogue, >-7-acetyl>amino>methyl>-7-oxabicyclohept-2-yl>-5-heptenoic acid ((-)-7) was found to be a potent and selective thromboxane A2 (TxA2) receptor antagonist.Unlike the related series of ω-chain allylic alcohols, amide 7 and its congeners were uniformly free of direct contractile activity in vitro (bovine coronary) and in vivo (anesthetized guinea pig).Amide 7 was effective in the inhibition of (a) arachidonic acid induced platelet aggregation of human platelet-richplasma (I50 = 0.18 +/- 0.006 μM), (b) 11,9-epoxymethano-PGH2 induced platelet aggregation of human platelet-rich plasma (I50 = 0.24 μM), (c) 11,9-epoxymethano-PGH2 induced contraction of guinea pig trachea (Kb = 3.0 +/- 0.3 nM) or rat aorta (Kb = 8.8 +/- 1.1 nM), and (d) arachidonic acid induced bronchoconstriction in the anesthetized guinea pig (0.1-1.0 mg/kg iv).Amide 7 inhibited the binding of ->-7-hydrazino>methyl>-7-oxabicyclohept-2-yl>-5-heptenoic acid to human platelet membranes in a specific and saturable manner with a Kd = 49.6 +/- 1.4 nM.