107834-03-7Relevant articles and documents
The Suzuki-Miyaura cross coupling reactions on solid support. Link to solution phase directed ortho metalation. The Leznoff acetal linker approach to biaryl and heterobiaryl aldehydes
Chamoin,Houldsworth,Kruse,Bakker, W. Iwema,Snieckus
, p. 4179 - 4182 (1998)
The synthesis of the titled compounds by Suzuki-Miyaura cross coupling on Merrifield resin - Leznoff acetal - linked halo benzaldehydes followed by mild acid hydrolysis is reported; synthetic utility for heterocycles based on solution phase Directed ortho Metalation chemistry is demonstrated.
PALLADIUM-CATALYZED ARYLATION OF FURAN, THIOPHENE, BENZOFURAN AND BENZOTHIOPHENE
Ohta, Akihiro,Akita, Yasuo,Ohkuwa, Teruya,Chiba, Mari,Fukunaga, Ryuichi,et al.
, p. 1951 - 1958 (1990)
Treatment of ?-electron sufficient aromatic heterocycles such as furan, thiophene, benzofuran and benzothiophene with aryl bromides in the presence of tetrakis(triphenyphosphine)palladium gave the corresponding 2-aryl aromatic heterocycles.
A convenient microwave assisted arylzinc generation-Negishi coupling protocol
Mutule, Ilga,Suna, Edgars
, p. 3909 - 3912 (2004)
Arylzinc reagents were readily prepared from aryl iodides using a Zn-Cu couple in a microwave environment. A sequential arylzinc formation-Negishi cross-coupling protocol suitable for parallel high-throughput synthesis has been developed.
5-(Naphth-1-yl)- and 5-[(1,1'-biphenyl)-4-yl]isoxazole-3-carbaldehyde oximes: Synthesis, complexes with palladium, and application in catalysis
Potkin,Bumagin,Zelenkovskii,Petkevich,Livantsov,Golantsov
, p. 1782 - 1792 (2014)
1-(Naphth-1-yl)- and 1-[(1,1'-biphenyl)-4-yl-3,4,4-trichloro-3-buten-1-ones were synthesized by acylation of naphthalene and biphenyl with 3,4,4-trichloro-3-butenoyl chloride. Further reaction with hydroxylamine led to 5-(naphth-1-yl)- and 5-[(1,1'-biphen
High-turnover aminopyridine-based Pd-catalysts for Suzuki-Miyaura reaction in aqueous media
Bumagin, Nikolay A.
, p. 17 - 20 (2016)
A high-turnover catalytic system based on commercially available aminopyridines (L) and PdCl2 has been developed for Suzuki-Miyaura reaction in aqueous media. Reactions of arylboronic acids with a wide range of aryl iodides, bromides and chlorides proceeded in the presence of these catalysts for a short time in aqueous media to afford the cross-coupling products in high yields. Furthermore, this protocol allows tolerating a wide range of functional groups.
An effective activation of palladium phosphine complexes in aqueous phase reactions of hetero-aromatic boronic acids with aryl halides
Bumagin,Veselov,Belov
, p. 19 - 25 (2014)
We have developed a simple and effective method for the activation of palladium phosphine complexes in the Suzuki reaction (TON up to 9800, TOF up to 58800 h-1) by selecting an aqueous reaction medium instead of organic solvents. This method wa
Gold Catalysts Can Generate Nitrone Intermediates from a Nitrosoarene/Alkene Mixture, Enabling Two Distinct Catalytic Reactions: A Nitroso-Activated Cycloheptatriene/Benzylidene Rearrangement
Cheng, Mu-Jeng,Kardile, Rahul Dadabhau,Kuo, Tung-Chun,Liu, Rai-Shung,More, Sayaji Arjun
supporting information, p. 5506 - 5511 (2021/07/31)
Gold-catalyzed reactions of cycloheptatrienes with nitrosoarenes yield nitrone derivatives efficiently. This reaction sequence enables us to develop gold-catalyzed aerobic oxidations of cycloheptatrienes to afford benzaldehyde derivatives using CuCl and nitrosoarenes as co-catalysts (10-30 mol %). Our density functional theory calculations support a novel nitroso-activated rearrangement, tropylium → benzylidene. With the same nitrosoarenes, we developed their gold-catalyzed [2 + 2 + 1]-annulations between nitrosobenzene and two enol ethers to yield 5-alkoxyisoxazolidines using 1,4-cyclohexadienes as hydrogen donors.
EIF4E INHIBITORS AND USES THEREOF
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Paragraph 00630; 00639, (2021/09/11)
The present invention provides compounds inhibiting elF4E activity and compositions and methods of using thereof.
BENZIMIDAZOLE COMPOUNDS AND USE THEREOF FOR TREATING ALZHEIMER'S DISEASE OR HUNTINGTON'S DISEASE
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Page/Page column 13; 17; 18; 50, (2020/03/23)
Benzimidazole compounds of formula (I), shown below, are disclosed. The compounds are potent human glutaminyl cyclase inhibitors. Also disclosed is a pharmaceutical composition containing one of these compounds and a pharmaceutical acceptable carrier, as well as a method of treating Alzheimer's disease or Huntington's disease by administering to a subject in need thereof an effective amount of such a compound.