108149-99-1

Basic information

• Product Name: dimethyl (2S,3R)-2-fluoro-3-hydroxysuccinate
• CAS NO: 108149-99-1
• Molecular Weight: 180.133
• Mol File: 108149-99-1.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: dimethyl (2S,3R)-2-fluoro-3-hydroxysuccinate(CAS DataBase Reference)
• NIST Chemistry Reference: dimethyl (2S,3R)-2-fluoro-3-hydroxysuccinate(108149-99-1)
• EPA Substance Registry System: dimethyl (2S,3R)-2-fluoro-3-hydroxysuccinate(108149-99-1)

Safety Data

• Hazardous Substances Data: 108149-99-1(Hazardous Substances Data)

Upstream product

• 608-68-4 dimethyl L-tartrate 

Downstream Products

• 363-59-7 dimethyl α,α'-difluorosuccinate 

Relevant articles and documents

TREATMENT OF DIMETHYL (+)-L-TARTRATE WITH SULFUR TETRAFLUORIDE

Treatment of dimethyl (+)-L-tartrate (I) with sulfur tetrafluoride results in the formation of an intermediate, 2-fluoro-1,2-bis(methoxycarbonyl)ethyl fluorosulfite (II), which under the action of hydrogen fluoride, present in the reaction mixture, is converted into dimethyl (-)(2S:3S)-2-fluoro-3-hydroxysuccinate (III).The reaction of the latter with SF4 leads to dimethyl meso-2,3-difluorosuccinate (IV).The structure and configurations of the compounds obtained were established by 1H and 19F NMR.Treatment of dimethyl (+)-L-tartrate (I) with sulfur tetrafluoride in the presence of excessive hydrogen fluoride gave dimethyl meso-2,3-difluorosuccinate in 96percent yield.