363-59-7

Basic information

• Product Name: dimethyl α,α'-difluorosuccinate
• Synonyms: dimethyl α,α'-difluorosuccinate
• CAS NO: 363-59-7
• Molecular Weight: 182.124
• Mol File: 363-59-7.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: dimethyl α,α'-difluorosuccinate(CAS DataBase Reference)
• NIST Chemistry Reference: dimethyl α,α'-difluorosuccinate(363-59-7)
• EPA Substance Registry System: dimethyl α,α'-difluorosuccinate(363-59-7)

Safety Data

• Hazardous Substances Data: 363-59-7(Hazardous Substances Data)

Upstream product

• 453-18-9 methyl fluoroacetate 
• 405897-14-5 dimethyl tartrate 
• 608-68-4 dimethyl L-tartrate 
• 108149-99-1 dimethyl (2S,3R)-2-fluoro-3-hydroxysuccinate 
• 110-22-5 diacetyl peroxide 

Downstream Products

• 543-21-5 Cellocidin 

Relevant articles and documents

TREATMENT OF DIMETHYL (+)-L-TARTRATE WITH SULFUR TETRAFLUORIDE

Treatment of dimethyl (+)-L-tartrate (I) with sulfur tetrafluoride results in the formation of an intermediate, 2-fluoro-1,2-bis(methoxycarbonyl)ethyl fluorosulfite (II), which under the action of hydrogen fluoride, present in the reaction mixture, is converted into dimethyl (-)(2S:3S)-2-fluoro-3-hydroxysuccinate (III).The reaction of the latter with SF4 leads to dimethyl meso-2,3-difluorosuccinate (IV).The structure and configurations of the compounds obtained were established by 1H and 19F NMR.Treatment of dimethyl (+)-L-tartrate (I) with sulfur tetrafluoride in the presence of excessive hydrogen fluoride gave dimethyl meso-2,3-difluorosuccinate in 96percent yield.