1083-09-6

Basic information

• Product Name: 2,4,5-TRIMETHOXYAMPHETAMIN
• Synonyms: 2,4,5-TRIMETHOXYAMPHETAMIN;2,4,5-trimethoxyphenylisopropylamine;2,4,5-TRIMETHOXYAMPHETAMIN, >99% (HPLC);1-(2,4,5-Trimethoxyphenyl)-2-propanamine;2,4,5-TMA;2,4,5-Trimethoxyamphetamine;2,4,5-Trimethoxy-α-methylbenzeneethanamine;TMA-2
• CAS NO: 1083-09-6
• Molecular Formula: C₁₂H₁₉NO₃
• Molecular Weight: 225.2842
• Mol File: 1083-09-6.mol
• Article Data: 3

Chemical Properties

• Melting Point: 130 °C
• Boiling Point: 329.5°Cat760mmHg
• Flash Point: 155°C
• Appearance: /
• Density: 1.048g/cm³
• Vapor Pressure: 0.000234mmHg at 25°C
• Refractive Index: 1.519
• PKA: 9.54±0.10(Predicted)
• CAS DataBase Reference: 2,4,5-TRIMETHOXYAMPHETAMIN(CAS DataBase Reference)
• NIST Chemistry Reference: 2,4,5-TRIMETHOXYAMPHETAMIN(1083-09-6)
• EPA Substance Registry System: 2,4,5-TRIMETHOXYAMPHETAMIN(1083-09-6)

Safety Data

• Hazardous Substances Data: 1083-09-6(Hazardous Substances Data)

Usage

Description

2,4,5-TRIMETHOXYAMPHETAMIN, also known as TMA-2, is a psychedelic hallucinogen that has been found on the illicit drug market. It is a derivative of amphetamine, but unlike traditional amphetamines and cathinones, it does not affect monoamine re-uptake. Instead, TMA-2 has modest effects on the 5-HT2 serotonin receptors, specifically the 5-HT2A and 5-HT2C receptors. Due to its unique properties, this compound is primarily intended for research and forensic applications.

Uses

Used in Research Applications:
2,4,5-TRIMETHOXYAMPHETAMIN is used as a research chemical for studying the effects of psychedelic substances on the human brain and their potential therapeutic applications. Its unique interaction with the 5-HT2 serotonin receptors makes it a valuable tool in understanding the underlying mechanisms of hallucinogenic experiences and their potential benefits in treating various mental health disorders.
Used in Forensic Applications:
In the forensic field, 2,4,5-TRIMETHOXYAMPHETAMIN is used as a reference compound for the identification and analysis of illicit drugs. Its presence in drug samples can be detected and analyzed using various analytical techniques, such as mass spectrometry and chromatography, to help law enforcement agencies in their efforts to combat drug trafficking and abuse.
Used in Psychedelic Therapy Research:
2,4,5-TRIMETHOXYAMPHETAMIN is used as a psychedelic agent in research exploring the potential therapeutic benefits of hallucinogens in treating various mental health conditions, such as depression, anxiety, and post-traumatic stress disorder (PTSD). Its unique effects on the 5-HT2 serotonin receptors make it an interesting candidate for studying the mechanisms of action of psychedelic substances in the context of mental health treatment.
Used in Drug Synthesis and Design:
In the field of medicinal chemistry, 2,4,5-TRIMETHOXYAMPHETAMIN serves as a starting point for the synthesis and design of new compounds with potential therapeutic applications. By understanding the structure-activity relationship of TMA-2 and its interactions with the 5-HT2 serotonin receptors, researchers can develop novel compounds with improved pharmacological properties and reduced side effects.

InChI:InChI=1/C12H19NO3/c1-8(2)13-9-6-11(15-4)12(16-5)7-10(9)14-3/h6-8,13H,1-5H3

Upstream product

• 134040-35-0 2.4.5-trimethoxy-1-(2-nitro-cis-propenyl)-benzene 
• 494-40-6 asarone 
• 4460-86-0 asaraldehyde 
• 134040-35-0 2,4,5-trimethoxy-β-methyl-β-nitrostyrene 

Downstream Products

• 22199-15-1 (-)-3-(2,4,5-Trimethoxyphenyl)-isopropylamin 
• 22199-15-1 (+)-3-(2,4,5-Trimethoxyphenyl)-isopropylamin 

Relevant articles and documents

Discrimination and identification of the six aromatic positional isomers of trimethoxyamphetamine (TMA) by gas chromatography-mass spectrometry (GC-MS)

A reliable and accurate GC-MS method was developed that allows both mass spectrometric and chromatographic discrimination of the six aromatic positional isomers of trimethoxyamphetamine (TMA). Regardless of the trifluoroacetyl (TFA) derivatization, chromatographic separation of all the investigated isomers was achieved by using DB-5ms capillary columns (30 m x 0.32 mm i.d.), with run times less than 15 min. However, the mass spectra of the nonderivatized TMAs, except 2,4,6-trimethoxyamphetmine (TMA-6), showed insufficient difference for unambiguous discrimination. On the other hand, the mass spectra of the TFA derivatives of the six isomers exhibited fragments with significant intensity differences, which allowed the unequivocal identification of all the aromatic positional isomers investigated in the present study. This GC-MS technique in combination with TFA derivatization, therefore, is a powerful method to discriminate these isomers, especially useful to distinguish the currently controlled 3,4,5-trimethoxyamphetmine (TMA-1) and 2,4,5-trimethoxyamphetmine (TMA-2) from other uncontrolled TMAs. Copyright

Psychotomimetic amphetamines: methoxy 3,4-dialkoxyamphetamines.

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