108321-05-7

Basic information

• Product Name: 5-PHOSPHO-ALPHA-D-RIBOSYL DIPHOSPHATE SODIUM SALT
• Synonyms: P-RIB-PP;P-RIB-PP, PRPP SODIUM SALT;ALPHA-D-RIBOSYLDIPHOSPHATE 5-PHOSPHATE SODIUM SALT;5-PHOSPHO-ALPHA-D-RIBOSYL DIPHOSPHATE SODIUM SALT;5-PHOSPHO-D-RIBOSE 1-DIPHOSPHATE SODIUM SALT;5-PHOSPHORYLRIBOSE 1-PYROPHOSPHATE SODIUM SALT;5-phosphorylribose 1-pyrophosphate*sodium;5-PHOSPHO-D-RIBOSE 1-DIPHOSPHAT
• CAS NO: 108321-05-7
• Molecular Formula: C₅H₈O₁₄P₃*4Na
• Molecular Weight: 478
• Mol File: 108321-05-7.mol
• Article Data: 1

Chemical Properties

• Appearance: /
• Storage Temp.: −20°C
• Solubility: H2O: 50 mg/mL, clear, colorless to very faintly yellow
• BRN: 6043637
• CAS DataBase Reference: 5-PHOSPHO-ALPHA-D-RIBOSYL DIPHOSPHATE SODIUM SALT(CAS DataBase Reference)
• NIST Chemistry Reference: 5-PHOSPHO-ALPHA-D-RIBOSYL DIPHOSPHATE SODIUM SALT(108321-05-7)
• EPA Substance Registry System: 5-PHOSPHO-ALPHA-D-RIBOSYL DIPHOSPHATE SODIUM SALT(108321-05-7)

Safety Data

• Hazard Codes: Xn
• Statements: 20/21/22-68/20/21/22
• Safety Statements: 36/37
• WGK Germany: 3
• F: 10-21
• Hazardous Substances Data: 108321-05-7(Hazardous Substances Data)

Usage

Chemical Properties

White powder

Uses

5-Phospho-D-ribose 1-Diphosphate is a natural intermediate involved in the pentose phosphate pathway leading to purine, pyrimidine, and histidine metabolism.

InChI:InChI=1/C5H13O14P3.4Na/c6-3-2(1-16-20(8,9)10)17-5(4(3)7)18-22(14,15)19-21(11,12)13;;;;/h2-7H,1H2,(H,14,15)(H2,8,9,10)(H2,11,12,13);;;;/q;4*+1/p-4/t2-,3-,4-,5-;;;;/m1..../s1

Upstream product

• 532-20-7 D-Ribose 
• 108321-99-9 α,β-D-ribofuranose-5-phophate disodium salt 
• 4578-31-8 adenosine-5'-monophosphate disodium salt 

Downstream Products

• 3387-36-8 disodium uridine-5'-monophosphate 

Relevant articles and documents

Practical Synthesis of 5-Phospho-D-ribosyl α-1-pyrophosphate (PRPP): Enzymatic Routes from Ribose 5-Phosphate or Ribose

This paper describes enzymatic syntheses of 5-phospho-D-ribosyl α-1-pyrophosphate (PRPP) on a 75-mmol scale.The reactions used PAN-immobilized PRPP synthetase as catalyst with in situ ATP-cofactor regeneration.In one procedure pure r-5-P was used as a starting material; in a second, r-5-P was synthesized by ribokinase-catalyzed phosphorilation of D-ribose and used in situ.The potential for use of PRPP as a starting material for the preparation of nucleotides was demonstrated by an enzymatic synthesis of UMP.This paper also describes several methods for the preparation of r-5-P: acid-catalyzed hydrolysis of AMP, acid-catalyzed hydrolysis of crude mononucleotide mixture obtained by digestion of RNA, chemical synthesis from D-ribose, and ribokinase-catalyzed synthesis from D-ribose.Procedures are described for the isolation of PRPP synthetase (from Salmonella typhimurium) and ribokinase (from Lactobacillus plantarum) and for immobilization of these enzymes in PAN.