108587-40-2

Basic information

• Product Name: N-(BENZLOXYCARBONYL)-3-AMINO-1 2-
• Synonyms: N-(BENZLOXYCARBONYL)-3-AMINO-1 2-;N-(BENZYLOXYCARBONYL)-3-AMINO-1,2-PROPAN;N-(Benzyloxycarbonyl)-3-amino-1,2-propanediol 97%
• CAS NO: 108587-40-2
• Molecular Formula: C₁₁H₁₅NO₄
• Molecular Weight: 225.242
• Product Categories: Amino Alcohols;Organic Building Blocks;Oxygen Compounds;Amino Alcohols;Building Blocks;Chemical Synthesis;Organic Building Blocks;Oxygen Compounds
• Mol File: 108587-40-2.mol
• Article Data: 10

Chemical Properties

• Melting Point: 74-78 °C(lit.)
• Boiling Point: 456.1oC at 760 mmHg
• Flash Point: 229.6oC
• Appearance: /
• Density: 1.255g/cm3
• Vapor Pressure: 4.12E-09mmHg at 25°C
• Refractive Index: 1.56
• CAS DataBase Reference: N-(BENZLOXYCARBONYL)-3-AMINO-1 2-(CAS DataBase Reference)
• NIST Chemistry Reference: N-(BENZLOXYCARBONYL)-3-AMINO-1 2-(108587-40-2)
• EPA Substance Registry System: N-(BENZLOXYCARBONYL)-3-AMINO-1 2-(108587-40-2)

Safety Data

• WGK Germany: 3
• Hazardous Substances Data: 108587-40-2(Hazardous Substances Data)

Usage

General Description

N-(Benzloxycarbonyl)-3-amino-1,2-propanediol is a chemical compound with a molecular formula C11H15NO5. It is commonly used as a reagent in organic chemistry for the protection of amino groups. It is synthesized by reacting benzyl chloroformate with 3-amino-1,2-propanediol in the presence of a base. N-(BENZLOXYCARBONYL)-3-AMINO-1 2- is often used in the synthesis of peptides and as a building block for other organic molecules. It is important in the field of medicinal chemistry for the synthesis of pharmaceutical compounds.

InChI:InChI=1/C11H15NO4/c13-7-10(14)6-12-11(15)16-8-9-4-2-1-3-5-9/h1-5,10,13-14H,6-8H2,(H,12,15)

Upstream product

• 1262306-22-8 benzyloxycarbonylamino-4-chlorobenzoate 
• 107-18-6 allyl alcohol 
• 616-30-8 3-Amino-1,2-propanediol 
• 501-53-1 benzyl chloroformate 

Downstream Products

• 125907-47-3 C₂₃H₄₃NO₄Si₂ 
• 108587-42-4 Hexadecanoic acid 1-(benzyloxycarbonylamino-methyl)-2-trityloxy-ethyl ester 
• 108587-45-7 C₃₂H₅₇N₂O₈P 
• 108587-44-6 Hexadecanoic acid 1-(benzyloxycarbonylamino-methyl)-2-[(2-bromo-ethoxy)-hydroxy-phosphoryloxy]-ethyl ester 
• 108587-43-5 Hexadecanoic acid 2-benzyloxycarbonylamino-1-hydroxymethyl-ethyl ester 
• 15791-08-9 4,6-dichloro-2-hydroxy-1,3,5-triazine 
• 182680-62-2 3-(N-benzyloxycarbonyl)amino-2-hydroxypropionaldehyde 
• 108587-41-3 (2-Hydroxy-3-trityloxy-propyl)-carbamic acid benzyl ester 
• 137618-54-3 1-benzyloxy-3-((benzyloxycarbonyl)amino)propan-2-ol 
• 137618-70-3 2-benzyloxy-3-((benzyloxycarbonyl)amino)propanol 

Relevant articles and documents

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Regioselective base-free intermolecular aminohydroxylations of hindered and functionalized alkenes

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Peptidyl difluorodiol renin inhibitors

A renin inhibiting compound of the formula: wherein A is a functional group; W is (1)-C(O)-,(2)-CH(OH)-or(3)-N(R?)-wherein R? is hydrogen or loweralkyl; U is (1)-C(O)-,(2)-CH?-or(3)-N(R?)-wherein R? is hydrogen or lower alkyl, with the proviso that when W is-CH(OH)-then U is-CH?-and with the proviso that U is-C(O)-or-CH?-when W is-N(R?)-; V is (1)-CH-,(2)-C(OH)-or(3)-C(halogen)-with the proviso that v is-CH--when U is-N(R?)-; Q is-CH(R?)-or-C(=CHR1a)-wherein R? is (1) loweralkyl,(2) cycloalkylalkyl,(3) arylalkyl,(4) (heterocyclic) alkyl,(5) 1-benzyloxyethyl,(6) phenoxy,(7) thiophenoxy or(8) anilino, provided that B is-CH?-or-CH(OH)-or A is hydrogen when R? is phenoxy, thiophenoxy or anilino and R1a is aryl or heterocyclic; R? is a functional group; R? is (1) loweralkyl,(2) cycloalkylmethyl or(3) benzyl; R? is-CH(OH)-or-C(O)-; R? is-CH(OH)-or-C(O)-; and Z is (1) lower alkyl,(2) aryl,(3) arylalkyl,(4) cycloalkyl,(5) cycloalkylalkyl,(6) heterocyclic or(7) (heterocyclic)alkyl; or a pharmaceutically acceptable salt, ester or prodrug thereof.