108825-05-4 Usage
Description
C21H26ClNO2, also known as Clemastine N-Oxide, is a metabolite of Clemastine Fumarate (C568500). It is a derivative of an H1 histamine receptor antagonist and antihistaminic.
Used in Pharmaceutical Industry:
C21H26ClNO2 is used as a metabolite for understanding the metabolic pathways and effects of Clemastine Fumarate, which is an H1 histamine receptor antagonist and antihistaminic. This knowledge can help in the development of improved antihistamine drugs and in assessing the safety and efficacy of Clemastine Fumarate.
Check Digit Verification of cas no
The CAS Registry Mumber 108825-05-4 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,0,8,8,2 and 5 respectively; the second part has 2 digits, 0 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 108825-05:
(8*1)+(7*0)+(6*8)+(5*8)+(4*2)+(3*5)+(2*0)+(1*5)=124
124 % 10 = 4
So 108825-05-4 is a valid CAS Registry Number.
108825-05-4Relevant articles and documents
Structural elucidation of N-oxidized clemastine metabolites by liquid chromatography/tandem mass spectrometry and the use of Cunninghamella elegans to facilitate drug metabolite identification
Aberg, Annica Tevell,Loefgren, Helena,Bondesson, Ulf,Hedeland, Mikael
, p. 1447 - 1456 (2010)
Cunninghamella elegans is a filamentous fungus that has been shown to biotransform drugs into the same metabolites as mammals. In this paper we describe the use of C. elegans to aid the identification of clemastine metabolites since high concentrations of
