1091820-63-1Relevant articles and documents
Microwave-induced one-pot synthesis of pyrimidine-2(1H)-one derivatives as anti-inflammatory agents
Sahoo, Biswa Mohan,Banik, Bimal Krishna,Mahato, Arun Kumar
, p. 1301 - 1305 (2020/06/27)
A series of pyrimidine-2(1H)-one derivative were obtained by multi-component one-pot synthesis under microwave irradiation. Equimolar quantities of ethylacetoacetate, substituted benzaldehydes and urea undergo condensation followed by cyclizaton in presence of aqueous solution of sodium hydroxide to produce corresponding pyrimidine derivatives. With the help of microwave heating, there is clean reaction with shorter reaction time, environmental-friendly, improved yield as compared to conventional heating method. The structures of the newly synthesized compounds have been established on the basis of their IR, NMR spectral data. These compounds were screened for their anti-inflammatory activity. Some of them were found to possess significant activity as compared to standard drug.
Palladium-catalyzed dehydrogenation of dihydro-heterocycles using isoprene as the hydrogen acceptor without oxidants
Liu, Xiao-Jun,Wang, Wen-Peng,Huo, Cong-De,Wang, Xi-Cun,Quan, Zheng-Jun
, p. 565 - 569 (2017/08/14)
An efficient and general method for Pd-catalyzed dehydrogenative aromatization of dihydro-heteroatom compounds without external O2 and H2 is first described. The protocol firstly uses isoprene as a hydrogen acceptor. Various dihydro-
Synthesis of 4-aminoquinoline - Pyrimidine hybrids as potent antimalarials and their mode of action studies
Singh, Kamaljit,Kaur, Hardeep,Chibale, Kelly,Balzarini, Jan
, p. 314 - 323 (2013/10/01)
One of the most viable options to tackle the growing resistance to the antimalarial drugs such as artemisinin is to resort to synthetic drugs. The multi-target strategy involving the use of hybrid drugs has shown promise. In line with this, new hybrids of