5948-71-0 Usage
Description
4-(4-Chloro-phenyl)-6-methyl-2-oxo-1,2,3,4-tetrahydro-pyrimidine-5-carboxylic acid ethyl ester is a chemical compound that belongs to the class of pyrimidine derivatives. It is characterized by its molecular structure, which includes a pyrimidine ring fused with a tetrahydro ring and an ester functional group. 4-(4-Chloro-phenyl)-6-methyl-2-oxo-1,2,3,4-tetrahydro-pyrimidine-5-carboxylic acid ethyl ester is known for its potential applications in various fields, particularly in the synthesis of pharmaceuticals and other organic compounds.
Uses
Used in Organic Synthesis:
4-(4-Chloro-phenyl)-6-methyl-2-oxo-1,2,3,4-tetrahydro-pyrimidine-5-carboxylic acid ethyl ester is used as an organic synthesis intermediate for the preparation of various organic compounds. Its unique molecular structure allows it to serve as a building block in the synthesis of complex molecules, which can be further modified or functionalized to achieve desired properties.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, 4-(4-Chloro-phenyl)-6-methyl-2-oxo-1,2,3,4-tetrahydro-pyrimidine-5-carboxylic acid ethyl ester is used as a pharmaceutical intermediate. It plays a crucial role in the development of new drugs, particularly those targeting specific biological pathways or receptors. Its structural diversity and versatility make it a valuable component in the design and synthesis of novel therapeutic agents.
Used in Laboratory Research and Development:
4-(4-Chloro-phenyl)-6-methyl-2-oxo-1,2,3,4-tetrahydro-pyrimidine-5-carboxylic acid ethyl ester is also utilized in laboratory research and development processes. It serves as a valuable tool for chemists and researchers to study the properties and reactivity of pyrimidine derivatives, as well as to explore new synthetic routes and methodologies. 4-(4-Chloro-phenyl)-6-methyl-2-oxo-1,2,3,4-tetrahydro-pyrimidine-5-carboxylic acid ethyl ester can be used to investigate various aspects of chemical reactions, such as reaction mechanisms, stereochemistry, and selectivity.
Used in Chemical Production Process:
In the chemical production process, 4-(4-Chloro-phenyl)-6-methyl-2-oxo-1,2,3,4-tetrahydro-pyrimidine-5-carboxylic acid ethyl ester is employed as a key intermediate in the synthesis of various chemicals and materials. Its presence in the production process can lead to the development of new products with improved properties, such as enhanced stability, reactivity, or bioavailability. Additionally, it can contribute to the optimization of existing chemical processes, resulting in more efficient and cost-effective production methods.
Synthesis
Substituted benzaldehyde (6.617×10-3mmol; 1.0 equiv.) is mixed with slightly excess equivalent of urea (6.749×10-3mmol; 1.02 equiv.) and ethyl acetoacetate (6.749×10-3mmol; 1.02 equiv.) in the presence of catalytic concentration 1.0×10-4mmol of our synthesized dimeric pyridinium salts along with dry MeCN at ambient reaction condition from 6-33 min. reaction condition. Yield: 92%
Check Digit Verification of cas no
The CAS Registry Mumber 5948-71-0 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 5,9,4 and 8 respectively; the second part has 2 digits, 7 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 5948-71:
(6*5)+(5*9)+(4*4)+(3*8)+(2*7)+(1*1)=130
130 % 10 = 0
So 5948-71-0 is a valid CAS Registry Number.
InChI:InChI=1/C14H15ClN2O3/c1-3-20-13(18)11-8(2)16-14(19)17-12(11)9-4-6-10(15)7-5-9/h4-7,12H,3H2,1-2H3,(H2,16,17,19)
5948-71-0Relevant articles and documents
Potassium Fluoride-Modified Clay as a Reusable Heterogeneous Catalyst for One-Pot Synthesis of 3,4-Dihydropyrimidin-2(1H)-ones
Bentahar,Taleb, M. Ait,Sabour,Dbik,El Khomri,El Messaoudi,Lacherai,Mamouni
, p. 1423 - 1431 (2019)
Potassium fluoride-modified clay collected from the region of Agadir (Morocco) was used as a hetaerogeneous catalyst in the one-pot synthesis of 3,4-dihydropyrimidine-2(1H)-one derivatives via the Biginelli reaction. The products were obtained with excell
Copper-catalyzed one-pot relay synthesis of anthraquinone based pyrimidine derivative as a probe for antioxidant and antidiabetic activity
Ahmad, Zaheer,Arshad, Uzma,Parveen, Shagufta,Rafiq, Naila,Shafiq, Nusrat,Zarren, Gul
, (2020/12/17)
Synthetic compounds have modernized the globe due to its vast applicable fields. Anthraquinones, as well as pyrimidine derivatives, are used as essential pharmacophores in the field of medicine. Maintenance of a green disease-free environment by using these derivatives is being acknowledged in developed as well as developing countries of the world. Considering the use of active catalysts in the synthesis of anthraquinone based derivatives are the era of concern for researchers due to their distinctive properties. Owing to the remarkable activities of anthraquinone and pyrimidine derivative, we synthesize compounds having both functionalities with the utilization of novel synergically active copper catalysts. This study explores the application of synthesized compounds using fast, ecofriendly and cost-effective approaches.1H and 13C NMR, antioxidant, antidiabetic, molecular docking and QSAR studies were used for characterization and evaluation of newly synthesized anthraquinone based pyrimidine derivatives. The result of these techniques shows that our desired compounds were successfully synthesized and have potent applications. Among all synthesized compounds, G2 and G3 showed a remarkable antioxidant activity with IC50 of 15.09 and 21.88 μg/ml respectively. While the compound G2 and G4 showed a strong inhibitory antidiabetic activity with the IC50 value of 24.23 and 28.94 μg/ml respectively. Furthermore, molecular docking results for both of the proteins assist the experimental data and confirms the different interactions between binding domains and substituent moieties. SAR study also relates to the experimental facts by giving us positive results of synthesized compounds. According to the QSAR study, G4 and G2 emerged as the most stable and most reactive compound among other compounds respectively. While MEP shows moderate to good nucleophilic and electrophilic reactivity of all four compounds.
Fabrication of porous ultrathin carbon nitride nanosheet catalysts with enhanced photocatalytic activity for N- And O-heterocyclic compound synthesis
Li, Yancong,Ma, Jiliang,Liu, Zhendong,Jin, Dongnv,Jiao, Gaojie,Guo, Yanzhu,Wang, Qiang,Zhou, Jinghui,Sun, Runcang
, p. 365 - 372 (2021/01/11)
A simple and efficient photocatalytic method for the synthesis of dihydropyrimidinones (DHPMs) and their derivatives via porous ultrathin carbon nitride nanosheets (p-CNNs) without solvents was demonstrated. The yields of 3,4-dihydropyrimidin-2(1H)-ones/t
