1092371-30-6

Basic information

• Product Name: 9-{4-[(3-chloro-phenylamino)-methyl]-[1,2,3]triazol-1-yl}-5-(3,4,5-trimethoxy-phenyl)-5,8,8a,9-tetrahydro-5aH-furo[3',4':6,7]naphtho[2,3-d][1,3]dioxol-6-one
• Synonyms: 9-{4-[(3-chloro-phenylamino)-methyl]-[1,2,3]triazol-1-yl}-5-(3,4,5-trimethoxy-phenyl)-5,8,8a,9-tetrahydro-5aH-furo[3',4':6,7]naphtho[2,3-d][1,3]dioxol-6-one
• CAS NO: 1092371-30-6
• Molecular Weight: 605.047
• Mol File: 1092371-30-6.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 9-{4-[(3-chloro-phenylamino)-methyl]-[1,2,3]triazol-1-yl}-5-(3,4,5-trimethoxy-phenyl)-5,8,8a,9-tetrahydro-5aH-furo[3',4':6,7]naphtho[2,3-d][1,3]dioxol-6-one(CAS DataBase Reference)
• NIST Chemistry Reference: 9-{4-[(3-chloro-phenylamino)-methyl]-[1,2,3]triazol-1-yl}-5-(3,4,5-trimethoxy-phenyl)-5,8,8a,9-tetrahydro-5aH-furo[3',4':6,7]naphtho[2,3-d][1,3]dioxol-6-one(1092371-30-6)
• EPA Substance Registry System: 9-{4-[(3-chloro-phenylamino)-methyl]-[1,2,3]triazol-1-yl}-5-(3,4,5-trimethoxy-phenyl)-5,8,8a,9-tetrahydro-5aH-furo[3',4':6,7]naphtho[2,3-d][1,3]dioxol-6-one(1092371-30-6)

Safety Data

• Hazardous Substances Data: 1092371-30-6(Hazardous Substances Data)

Upstream product

• 64798-32-9 3-chloro-N-(prop-2-ynyl)aniline 
• 155252-34-9 4β-azido-4-deoxypodophyllotoxin 

Relevant articles and documents

Studies on novel 4β-[(4-substituted)-1,2,3-triazol-1-yl] podophyllotoxins as potential anticancer agents

A series of 4β-[(4-substituted)-1,2,3-triazol-1-yl] podophyllotoxin congeners have been designed and synthesized with significant regioselectivity by employing Cu(I) catalyzed 1,3-dipolar cycloaddition reaction of C4β-azido podophyllotoxin and C4β-azido-4′-O-demethyl podophyllotoxin with N-prop-2-yn-1-ylanilines. These compounds were evaluated for anticancer activity against a panel of seven human cancer cell lines. It was interesting to note that all the compounds exhibited promising activity especially against SF-295 (CNS), HCT-15 (colon) and 502713 (colon) cell lines. Compound 11e was found to be the most promising in this study.