109473-36-1

Basic information

• Product Name: N-tert-butyloxycarbonylaminoisophthalimide
• Synonyms: N-tert-butyloxycarbonylaminoisophthalimide
• CAS NO: 109473-36-1
• Molecular Weight: 262.265
• Mol File: 109473-36-1.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: N-tert-butyloxycarbonylaminoisophthalimide(CAS DataBase Reference)
• NIST Chemistry Reference: N-tert-butyloxycarbonylaminoisophthalimide(109473-36-1)
• EPA Substance Registry System: N-tert-butyloxycarbonylaminoisophthalimide(109473-36-1)

Safety Data

• Hazardous Substances Data: 109473-36-1(Hazardous Substances Data)

Upstream product

• 85-44-9 phthalic anhydride 

Downstream Products

• 16437-59-5 phthalic acid hydrazide 
• 287729-00-4 N-benzyl-N-tert-butyloxycarbonylaminophthalimide 
• 259870-74-1 tert-butyl 1-cyclopentylhydrazinecarboxylate 
• 147688-34-4 tert-butyl 1-benzylhydrazine-1-carboxylate 
• 21075-86-5 (tert-butoxy)-N-(prop-2-en-1-yl)carbohydrazide 
• 21075-83-2 1-methyl-1-tert-butoxycarbonylhydrazine 

Relevant articles and documents

New Synthesis of 1,1-Substituted Hydrazines by Alkylation of N-Acyl- or N-alkyloxycarbonylaminophthalimide Using the Mitsunobu Protocol

N-acyl- and N-alkoxycarbonylaminophthalimides are prepared using a convenient reaction and are efficiently used as acid partners in Mitsunobu reaction. This reaction allows them to be alkylated by primary, secondary or benzyl groups. Comparison of the reactivities and pKa values of these N-substituted aminophthalimides suggest that the success of the Mitsunobu reaction in this case seems to be governed more by steric than by electronic effects. A final dephthaloylation step results in an efficient method for the preparation of 1,1-substituted hydrazines.