1095173-26-4 Usage
Description
(2R,4R)-tert-butyl 2-((2-aminophenyl)carbamoyl)-4-(3-(4-cyanophenyl)ureido)piperidine-1-carboxylate is a complex organic molecule with a piperidine backbone and multiple functional groups. It features a tert-butyl group, a carbamate group, an aminophenyl group, and a cyanophenyl group, along with two ureido groups. The carboxylate ester has a specific stereochemistry of (2R,4R), indicating the configuration of the substituents on the piperidine ring. (2R,4R)-tert-butyl 2-((2-aminophenyl)carbamoyl)-4-(3-(4-cyanophenyl)ureido)piperidine-1-carboxylate's structural complexity and the presence of various functional groups suggest potential pharmaceutical activity and applications in chemical synthesis and catalysis.
Uses
Used in Pharmaceutical Industry:
(2R,4R)-tert-butyl 2-((2-aminophenyl)carbamoyl)-4-(3-(4-cyanophenyl)ureido)piperidine-1-carboxylate is used as a potential pharmaceutical candidate due to its complex structure and multiple functional groups. The presence of the carbamate, aminophenyl, and cyanophenyl groups may contribute to its interaction with biological targets, making it a promising molecule for the development of new drugs.
Used in Chemical Synthesis:
(2R,4R)-tert-butyl 2-((2-aminophenyl)carbamoyl)-4-(3-(4-cyanophenyl)ureido)piperidine-1-carboxylate is used as a building block in chemical synthesis for the creation of new compounds. Its structural complexity and functional groups can be utilized to form a variety of derivatives, potentially leading to the discovery of novel molecules with unique properties and applications.
Used in Catalysis:
(2R,4R)-tert-butyl 2-((2-aminophenyl)carbamoyl)-4-(3-(4-cyanophenyl)ureido)piperidine-1-carboxylate is used as a catalyst or catalyst precursor in various chemical reactions. The presence of the ureido groups and the carboxylate ester functionality may enable it to facilitate or enhance the rate of certain reactions, making it a valuable component in catalytic processes.
Check Digit Verification of cas no
The CAS Registry Mumber 1095173-26-4 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,0,9,5,1,7 and 3 respectively; the second part has 2 digits, 2 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 1095173-26:
(9*1)+(8*0)+(7*9)+(6*5)+(5*1)+(4*7)+(3*3)+(2*2)+(1*6)=154
154 % 10 = 4
So 1095173-26-4 is a valid CAS Registry Number.
1095173-26-4Relevant articles and documents
Discovery of PF-04449913, a potent and orally bioavailable inhibitor of smoothened
Munchhof, Michael J.,Li, Qifang,Shavnya, Andrei,Borzillo, Gary V.,Boyden, Tracey L.,Jones, Christopher S.,Lagreca, Susan D.,Martinez-Alsina, Luis,Patel, Nandini,Pelletier, Kathleen,Reiter, Larry A.,Robbins, Michael D.,Tkalcevic, George T.
, p. 106 - 111 (2012/04/04)
Inhibitors of the Hedgehog signaling pathway have generated a great deal of interest in the oncology area due to the mounting evidence of their potential to provide promising therapeutic options for patients. Herein, we describe the discovery strategy to overcome the issues inherent in lead structure 1 that resulted in the identification of Smoothened inhibitor 1-((2R,4R)-2-(1H-benzo[d] imidazol-2-yl)-1-methylpiperidin-4-yl)-3-(4-cyanophenyl)urea (PF-04449913, 26), which has been advanced to human clinical studies.
