321744-26-7

Basic information

• Product Name: (2R,4S)-N-BOC-4-HYDROXYPIPERIDINE-2-CARBOXYLIC ACID METHYL ESTER
• Synonyms: METHYL (2R,4S)-N-BOC-4-HYDROXYPIPERIDINE-2-CARBOXYLATE;(2R,4S)-N-BOC-4-HYDROXYPIPERIDINE-2-CARBOXYLIC ACID METHYL ESTER;(2R,4S)-N-boc-4-Hydroxypiperidine-2-carboxylicacidmethylester(e.e.);(2R,4S)-N-BOC-4-HYDROXYPIPERIDINE-2-CARBO-XYLIC ACID METHYL ESTER 95% (98% E.E.);(2R,4S)-N-BOC-4-Hydroxypiperidine-2-carboxylic acid methyl ester, 98% ee;(2R,4S)-N-Boc-4-Hydroxypiperidine-2-carboxylic acid methyl ester (Methyl (2R,4S)-N-Boc-4-hydroxypiperidine-2-carboxylate);1-(tert-Butyl) 2-methyl (2R,4S)-4-hydroxypiperidine-1,2-dicarboxylate;(2R,4S)-N-BOC-4-Hydroxypiperidine-2-carboxylic aci
• CAS NO: 321744-26-7
• Molecular Formula: C₁₂H₂₁NO₅
• Molecular Weight: 259.3
• Product Categories: API intermediates
• Mol File: 321744-26-7.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 402.56°C (rough estimate)
• Flash Point: 166.8 °C
• Appearance: Colorless to amber/Viscous Liquid or Waxy Mass
• Density: 1.182
• Refractive Index: 1.4596 (estimate)
• Storage Temp.: Refrigerator (+4°C)
• PKA: 14.39±0.40(Predicted)
• CAS DataBase Reference: (2R,4S)-N-BOC-4-HYDROXYPIPERIDINE-2-CARBOXYLIC ACID METHYL ESTER(CAS DataBase Reference)
• NIST Chemistry Reference: (2R,4S)-N-BOC-4-HYDROXYPIPERIDINE-2-CARBOXYLIC ACID METHYL ESTER(321744-26-7)
• EPA Substance Registry System: (2R,4S)-N-BOC-4-HYDROXYPIPERIDINE-2-CARBOXYLIC ACID METHYL ESTER(321744-26-7)

Safety Data

• Safety Statements: 24/25
• Hazardous Substances Data: 321744-26-7(Hazardous Substances Data)

Usage

Chemical Properties

Colorless to amber viscous liquid or waxy mass

Upstream product

• 24424-99-5 di-tert-butyl dicarbonate 
• 475504-31-5 (2R,4S)-4-hydroxypipecolic acid methyl ester 
• 475504-29-1 (2R)-4-formylpipecolic acid methyl ester 
• 50299-14-4 N-Acetyl-α-allylglycine 
• 127515-28-0 (R)-methyl 2-[N-(benzyloxycarbonyl)amino]-4-pentenoate 
• 127474-54-8 (R)-2-(benzyloxycarbonylamino)pent-4-enoic acid 
• 177944-17-1 methyl (2R,4S)-4-hydroxy-1-((R)-1-phenylethyl)piperidine-2-carboxylate 
• 211058-81-0 methyl (2R,4S)-4-hydroxy-2-piperidinecarboxylate 

Downstream Products

• 1413286-26-6 C₁₉H₂₅Cl₂NO₅ 
• 1095173-27-5 1-((2R,4R)-2-(1H-benzo[d]imidazol-2-yl)-1-methylpiperidin-4-yl)-3-(4-cyanophenyl)urea 
• 1095173-26-4 (2R,4R)-tert-butyl 2-((2-aminophenyl)carbamoyl)-4-(3-(4-cyanophenyl)ureido)piperidine-1-carboxylate 
• 1095173-20-8 (2R,4R)-1-(tert-butoxycarbonyl)-4-(3-(4-cyanophenyl)ureido)piperidine-2-carboxylic acid 
• 1095173-19-5 (2R,4R)-1-tert-butyl 2-methyl 4-(3-(4-cyanophenyl)ureido)piperidine-1,2-dicarboxylate 
• 1352568-43-4 C₂₁H₂₄N₄O₂ 
• 1352568-42-3 C₂₅H₃₂N₄O₅ 
• 1352568-41-2 C₁₉H₂₆N₂O₆ 
• 1352568-40-1 C₂₀H₂₈N₂O₆ 
• 1352568-39-8 (2R,4R)-tert-butyl 2-((2-aminophenyl)carbamoyl)-4-(2,3-dihydrobenzo[b][1,4]dioxine-6-carboxamido)piperidine-1-carboxylate 
• 778646-95-0 (2R,4R)-1-tert-butyl 2-methyl 4-aminopiperidine-1,2-dicarboxylate 
• 908294-14-4 1-tert-butyl 2-methyl (2R,4R)-4-({4-[(3-chloro-2-fluorophenyl)amino]-7-methoxyquinazolin-6-yl}oxy)piperidine-1,2-dicarboxylate 

Relevant articles and documents

The discovery of CCR3/H1 dual antagonists with reduced hERG risk

A series of dual CCR3/H1 antagonists based on a bispiperidine scaffold were discovered. Introduction of an acidic group overcame hERG liability. Bioavailability was optimised by modulation of physico-chemical properties and physical form to del

Synthesis of all isomers of pulcherrimine, a bitter principle in the sea urchin ovary

All eight isomers of pulcherrimine, a bitter principle of the sea urchin (Hemicentrotus pulcherrimus) ovary have been synthesized, which led to revision of the absolute stereochemistry of pulcherrimine. The synthetic pulcherrimine and the 2S isomer were highly bitter at a concentration of 1.0 mM.

Novel constrained CCK-B dipeptoid antagonists derived from pipecolic acid

A new series of 4-substituted pipecolic acid derivatives was prepared and incorporated into dipeptoids. The resulting products behave as moderately potent CCK-B antagonists but their constrained structure and its comparison with structurally related compounds yield valuable information about the conformational requirements for optimal recognition of the CCK-B receptor by antagonists.