109574-84-7Relevant articles and documents
Metal-Free Activation of C-I Bonds and Perfluoroalkylation of Alkenes with Visible Light Using Phosphine Catalysts
Helmecke, Lucas,Spittler, Michael,Baumgarten, Kai,Czekelius, Constantin
, p. 7823 - 7827 (2019)
An efficient metal-free, photomediated iodo perfluoroalkylation under mild conditions was developed. Using catalytic amounts (10 mol %) of phosphines and blue light irradiation, various olefins are transformed into the corresponding addition products with
Triethylborane-induced radical addition of halogenated compounds to alkenes and alkynes in water
Nakamura,Yorimitsu,Shinokubo,Oshima
, p. 1351 - 1352 (1998)
Treatment of a mixture of α-iodo-γ-butyrolactone and phenylacetylene in water with a catalytic amount of triethylborane provided the corresponding adduct in good yield via intermolecular radical addition reaction. The triethylborane-mediated radical react
Visible-Light-Mediated Iodoperfluoroalkylation of Alkenes in Flow and Its Application to the Synthesis of a Key Fulvestrant Intermediate
Rosso, Cristian,Williams, Jason D.,Filippini, Giacomo,Prato, Maurizio,Kappe, C. Oliver
supporting information, p. 5341 - 5345 (2019/07/03)
Two efficient continuous flow iodoperfluoroalkylation methods are described: using 0.05 mol % perylene diimide (PDI) photocatalyst under 450 nm irradiation or substoichiometric triethylamine under 405 nm irradiation. These methods enable dramatically elevated productivity versus batch processes. The triethylamine-mediated method is explored mechanistically and in substrate scope. The gram-scale synthesis of an active pharmaceutical ingredient side chain is also reported in flow, via a photochemical iodoperfluoroalkylation followed by hydrogenolysis.
METHOD FOR PRODUCING FLUORINATED COMPOUND
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Paragraph 0151; 0152; 0153; 0154-0156; 0157; 0177-0182, (2019/03/14)
This invention solves the problem of providing an efficient, new method for producing a fluoromethylene-containing compound. The problem can be solved by a method for producing a compound represented by formula (1) or a ring-closed or ring-opened derivative of the compound, wherein R1 represents an organic group, RX represents hydrogen or fluorine, R2a, R2b, R2c, and R2d are the same or different, and each represents —Y—R21 or —N(—R22)2, or R2b and R2c may join together to form a bond, wherein Y represents a bond, oxygen, or sulfur, R21 represents hydrogen or an organic group, and R22, in each occurrence, is the same or different and represents hydrogen or an organic group; the method comprising step A of reacting a compound represented by formula (2), wherein X represents a leaving group, and other symbols are as defined above, with a compound represented by formula (3), wherein the symbols are as defined above, in the presence of a reducing agent under light irradiation.