1096359-59-9

Basic information

• Product Name: {4-[2-(benzyl-ethyl-amino)-ethoxy]-3,5-diiodo-phenyl}-(2-butyl-benzofuran-3-yl)-methanone
• Synonyms: {4-[2-(benzyl-ethyl-amino)-ethoxy]-3,5-diiodo-phenyl}-(2-butyl-benzofuran-3-yl)-methanone
• CAS NO: 1096359-59-9
• Molecular Weight: 707.39
• Mol File: 1096359-59-9.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: {4-[2-(benzyl-ethyl-amino)-ethoxy]-3,5-diiodo-phenyl}-(2-butyl-benzofuran-3-yl)-methanone(CAS DataBase Reference)
• NIST Chemistry Reference: {4-[2-(benzyl-ethyl-amino)-ethoxy]-3,5-diiodo-phenyl}-(2-butyl-benzofuran-3-yl)-methanone(1096359-59-9)
• EPA Substance Registry System: {4-[2-(benzyl-ethyl-amino)-ethoxy]-3,5-diiodo-phenyl}-(2-butyl-benzofuran-3-yl)-methanone(1096359-59-9)

Safety Data

• Hazardous Substances Data: 1096359-59-9(Hazardous Substances Data)

Upstream product

• 60154-59-8 benzyl-(2-chloro-ethyl)-ethyl-amine 
• 1951-26-4 2-n-butyl-3-(3',5'-diiodo-4'-hydroxybenzoyl)benzofuran 

Downstream Products

• 96027-74-6 Desethylamiodarone hydrochloride 

Relevant articles and documents

Trace amine-associated receptor 1 (TAAR1) is activated by amiodarone metabolites

Amiodarone (Cordarone, Wyeth-Ayerst Pharmaceuticals) is a clinically available drug used to treat a wide variety of cardiac arrhythmias. We report here the synthesis and characterization of a panel of potential amiodarone metabolites that have significant structural similarity to thyroid hormone and its metabolites the iodothyronamines. Several of these amiodarone derivatives act as specific agonists of the G protein-coupled receptor (GPCR) trace amine-associated receptor 1 (TAAR1). This result demonstrates a novel molecular target for amiodarone derivatives with potential clinical significance.