110230-69-8

Basic information

• Product Name: 1,3-Propanediol, 2-phenyl-, monoacetate, (S)-
• CAS NO: 110230-69-8
• Molecular Formula: C11H14O3
• Molecular Weight: 194.23
• Mol File: 110230-69-8.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: 1,3-Propanediol, 2-phenyl-, monoacetate, (S)-(CAS DataBase Reference)
• NIST Chemistry Reference: 1,3-Propanediol, 2-phenyl-, monoacetate, (S)-(110230-69-8)
• EPA Substance Registry System: 1,3-Propanediol, 2-phenyl-, monoacetate, (S)-(110230-69-8)

Safety Data

• Hazardous Substances Data: 110230-69-8(Hazardous Substances Data)

Upstream product

• 98017-92-6 2-phenyl-1,3-propanediol diacetate 
• 54957-95-8 trans-2-methyl-5-phenyl-1,3-dioxane 
• 1570-95-2 2-phenylpropane-1, 3-diol 
• 79-20-9 acetic acid methyl ester 

Downstream Products

• 131682-38-7 (+)-3-acetoxy-2-phenylpropionic acid 
• 135879-78-6 (R)-1-acetoxy-2-phenyl-3-mesyloxypropane 
• 131605-52-2 1-acetoxy-3-benzyloxycarbonyloxy-2-phenylpropane 
• 135879-90-2 (S)-(-)-3-N-methylamino-2-phenylpropan-1-ol 
• 135879-81-1 1-acetoxy-3-(N-tert-butylamino)-2-phenylpropane 
• 135879-80-0 (S)-(+)-3-carbethoxyamino-2-phenylpropan-1-ol 
• 135879-79-7 (S)-(-)-1-acetoxy-3-azido-2-phenylpropane 
• 127298-25-3 (S)-(-)-3-amino-2-phenylpropan-1-ol 
• 135879-68-4 (S)-(-)-3-(N-tertbutylamino)-2-phenylpropan-1-ol 
• 16202-15-6 (S)-tropic acid 
• 17126-67-9 (+)-(R)-tropic acid 
• 131605-53-3 1-acetoxy-3-(4-nitrobenzyloxycarbonyloxy)-2-(4-nitrophenyl)propane 
• 131605-45-3 (-)-3-acetoxy-2-(4-aminophenyl)propan-1-ol 

Relevant articles and documents

Site-specific and asymmetric hydrolysis of prochiral 2-phenyl-1,3- propanediol diacetate by a bacterial esterase from an isolated strain

Bacillus cereus 809A and Burkholderia sp. 711C were isolated from soil. These strains demonstrate hydrolysis activity towards prochiral 2-phenyl-1,3-propanediol diacetate and accumulated the corresponding chiral monoacetates into the reaction mixture. When 2-phenyl 1,3-propanediol diacetate was used as a substrate, the produced monoacetates with Burkholderia sp. 711C were obtained in a racemic form but that produced by Bacillus cereus 809A showed an excess of the (S)-form. The resting cell reaction revealed that for Bacillus cereus 809A, there was an enrichment of one of the enantiomers of the monoacetate such that the enantiomeric excess (e.e.) of the (S)-form was over 95%. The purified enzyme from Bacillus cereus 809A hydrolyzed diacetate to monoacetate, and the e.e. value of the (S)-form increased by prolonged reaction in a way similar to the resting cell reaction. From N-terminal amino acids, this esterase is conserved in some strains of Bacillus for which the genomic sequences have been reported.

Acyclic phenylalkanediols as substrates for the study of enzyme recognition: Synthesis of substrates and enzymatic resolution via hydrolysis and transesterification

Different racemic or prochiral phenyl alkane (1,n)-diols were synthesized, and their resolution was carried out by two different strategies: enzymatic transesterification with vinyl acetate, or enzymatic hydrolysis of their corresponding diacetates, in both cases catalysed by porcine pancreatic lipase (PPL). The absolute configuration of the optically enriched reaction products was determined by formation of Mosher's esters or by the use of the Benzene Sector and Benzene Chirality Rules as obtained from the Circular Dichroism spectra.

Enzyme catalyzed monohydrolysis of 2-aryl-1 3-propanediol diacetates. A study of structural effects of the aryl moiety on the enantioselectivity

PPL catalyzed monohydrolysis of 2-aryl substituted 13-propanediol diacetates afforded the corresponding monoacetates in acceptable to fair chemical and optical yields. Electronic effects in the aromatic ring were examined. Elaboration of some 2-arylpropanediol monoacetates to optically active 2-arylpropanols and propanoic acids was performed.