110429-35-1 Usage
Description
Paroxetine-D4 HCl, also known as Paroxetine Hydrochloride, is a selective serotonin reuptake inhibitor (SSRI) used in the pharmaceutical industry. It is a white or almost white, crystalline powder that serves as an antidepressant and 5-HT uptake inhibitor. Paroxetine-D4 HCl is utilized in the treatment of various mental health disorders and has applications in research and quality control within the pharmaceutical sector.
Uses
Used in Pharmaceutical Industry:
Paroxetine-D4 HCl is used as an antidepressant for treating depression, panic attacks, obsessive-compulsive disorder (OCD), anxiety disorders, post-traumatic stress disorder, and a severe form of premenstrual syndrome (premenstrual dysphoric disorder).
Used in Research:
Paroxetine-D4 HCl is used as a research compound to study its effects on neural stem cells (NSCs) from embryonic rat hippocampus in vitro, as a CYP 2D6 inhibitor to study its effects on the in vitro production of phenolic metabolites by human recombinant CYP 2D6, and as an antidepressant to study its effects on the expression of pituitary adenylate cyclase activating polypeptide (PACAP), its receptors, and brain-derived neurotrophic factor (BDNF) in rat primary hippocampal neurons.
Used in Quality Control:
Paroxetine-D4 HCl serves as a pharmaceutical secondary standard, providing a convenient and cost-effective alternative to the preparation of in-house working standards for quality control in pharmaceutical laboratories and manufacturers.
Biochem/physiol Actions
Paroxetine hydrochloride hemihydrate is one of the most potent and selective of the selective serotonin reuptake inhibitors (SSRI); antidepressant
Check Digit Verification of cas no
The CAS Registry Mumber 110429-35-1 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,1,0,4,2 and 9 respectively; the second part has 2 digits, 3 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 110429-35:
(8*1)+(7*1)+(6*0)+(5*4)+(4*2)+(3*9)+(2*3)+(1*5)=81
81 % 10 = 1
So 110429-35-1 is a valid CAS Registry Number.
InChI:InChI=1/C19H20FNO3.ClH/c20-15-3-1-13(2-4-15)17-7-8-21-10-14(17)11-22-16-5-6-18-19(9-16)24-12-23-18;/h1-6,9,14,17,21H,7-8,10-12H2;1H/t14?,17-;/m0./s1
110429-35-1Relevant articles and documents
Diastereoconvergent Synthesis of (–)-Paroxetine
Chamorro-Arenas, Delfino,Fuentes, Lilia,Quintero, Leticia,Cruz-Gregorio, Silvano,H?pfl, Herbert,Sartillo-Piscil, Fernando
, p. 4104 - 4110 (2017/08/07)
A diastereoconvergent approach to (–)-paroxetine from diastereomeric 3,4-epoxy-2-piperidones is reported. For this synthesis, a regioselective and stereodivergent CuI-catalyzed epoxide-ring-opening reaction of epoxyamide precursors to give the 4-(4-fluorophenyl)-2-piperidone skeleton with the correct absolute configuration is crucial. Using CuBr·SMe2 as a catalyst, the epoxide-ring-opening reaction takes place with inversion of configuration; the configuration is retained when CuI is used.
Improved process for paroxetine hydrochloride substantially free from potential impurities
Gangula, Srinivas,Kolla, Naveen Kumar,Elati, Chandrasekar,Dongamanti, Ashok,Bandichhor, Rakeshwar
experimental part, p. 3344 - 3360 (2012/10/08)
An efficient process for production of paroxetine hydrochloride hemihydrate 1, a selective 5-hydroxytryptamine (serotonin) reuptake inhibitor, is described. Identification and control of potential impurities and establishment of efficient downstream workup procedures enabled us to produce paroxetine hydrochloride hemihydrate 1 efficiently.
Controlled Release Compositions of an Antidepressant Agent
-
, (2009/05/28)
The present invention relates to controlled release compositions comprising an anti-depressant compound. More particularly, the present invention relates to controlled release compositions comprising paroxetine hydrochloride.