64006-44-6 Usage
Description
Paroxetine maleate, also known as Aropax or Paxil, is a selective serotonin uptake inhibitor (SSRI) antidepressant. It is a maleate salt obtained by the reaction of paroxetine with one equivalent of maleic acid. Paroxetine maleate is a highly potent and selective 5-HT uptake inhibitor that binds with high affinity to the serotonin transporter (Ki = 0.05 nM). It displays minimal affinity for alpha1-, alpha2-, or beta-adrenoceptors, 5-HT2A, 5-HT1A, and D2 receptors.
Uses
Used in Pharmaceutical Industry:
Paroxetine maleate is used as an antidepressant for the treatment of various conditions in adults, including major depression, obsessive-compulsive disorder, and several anxiety disorders. It modulates the serotonin levels in the brain, providing relief from the symptoms of these conditions.
Used in Clinical Toxicology and Forensic Analysis:
Paroxetine maleate is used as a starting material for calibrators and controls in LC/MS or GC/MS paroxetine testing applications. These applications are essential for urine drug testing, prescription monitoring, clinical toxicology, and forensic analysis, ensuring the proper use and monitoring of the drug in various settings.
Used in Research and Development:
Paroxetine maleate is also utilized in research and development for the study of its interactions with biopolymers and macromolecules, as well as its potential applications in other therapeutic areas.
Biological Activity
Highly potent and selective 5-HT uptake inhibitor that binds with high affinity to the serotonin transporter (K i = 0.05 nM). K i values are 1.1, 350 and 1100 nM for inhibition of [ 3 H]-5-HT, [ 3 H]-l-NA and [ 3 H]-DA uptake respectively. Displays minimal affinity for a 1 -, a 2 - or b-adrenoceptors, 5-HT 2A , 5-HT 1A , D 2 or H 1 receptors at concentrations below 1000 nM, however displays weak affinity for muscarinic ACh receptors (K i = 42 nM). Antidepressant and anxiolytic in vivo .
Biochem/physiol Actions
Paroxetine is a strong cytochrome P450 2D6 isotype (CYP2D6) inhibitor, which reduces the effectiveness of tamoxifen. This phenylpiperidine derivative inhibits clozapine metabolism. Paroxetine is used to treat social phobia, obsessive-compulsive disorder and panic disorder. It is also used to treat the premenstrual dysphoric disorder, post-traumatic stress disorder and chronic headache.
Check Digit Verification of cas no
The CAS Registry Mumber 64006-44-6 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 6,4,0,0 and 6 respectively; the second part has 2 digits, 4 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 64006-44:
(7*6)+(6*4)+(5*0)+(4*0)+(3*6)+(2*4)+(1*4)=96
96 % 10 = 6
So 64006-44-6 is a valid CAS Registry Number.
InChI:InChI=1/C19H20FNO3/c20-15-3-1-13(2-4-15)17-7-8-21-10-14(17)11-22-16-5-6-18-19(9-16)24-12-23-18/h1-6,9,14,17,21H,7-8,10-12H2/p+1/t14-,17-/m0/s1
64006-44-6Relevant articles and documents
Pharmaceutical paroxetine-based organic salts of carboxylic acids with optimized properties: The identification and characterization of potential novel API solid forms
Carvalho, Paulo S.,Diniz, Luan F.,Tenorio, Juan C.,Souza, Matheus S.,Franco, Chris H. J.,Rial, Rafael C.,Warszawski De Oliveira, Karla Regina,Nazario, Carlos E. D.,Ellena, Javier
, p. 3668 - 3678 (2019/06/24)
Paroxetine hydrochloride, PRX HCl, is an important and widely prescribed antidepressant drug for anxiety and depression treatment. Since hydrochloride salts can cause problems in their manufacture, we have designed organic salts with oxalic, fumaric, male
4-Phenylpiperidine compounds for treating depression
-
, (2008/06/13)
The invention relates to a compound, and pharmaceutically acceptable salts, having the formula I: STR1 wherein: R represents an alkyl or alkynyl group having 1-4 carbon atoms, or a phenyl group optionally substituted by C1-4 alkyl, alkylthio, alkoxy, halogen, nitro, acylamino, methylsulfonyl or methylenedioxy, or represents tetrahydronaphthyl, R1 represents hydrogen, trifluoro (C1-4) alkyl, alkyl or alkynyl, X represents hydrogen, alkyl having 1-4 carbon atoms, alkoxy, trifluoroalkyl, hydroxy, halogen, methylthio or aralkoxy, R2 represents: a C1-C10 alkyl group, a phenyl group optionally substituted by one or more of the following groups: a C1-C10 alkyl group, a halogen group, a nitro group, hydroxy group, and/or an alkoxy group.
