1107014-53-8

Basic information

• Product Name: C₂₅H₂₅FN₄O₃
• CAS NO: 1107014-53-8
• Molecular Weight: 448.497
• Mol File: 1107014-53-8.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₂₅H₂₅FN₄O₃(CAS DataBase Reference)
• NIST Chemistry Reference: C₂₅H₂₅FN₄O₃(1107014-53-8)
• EPA Substance Registry System: C₂₅H₂₅FN₄O₃(1107014-53-8)

Safety Data

• Hazardous Substances Data: 1107014-53-8(Hazardous Substances Data)

Upstream product

• 1024604-75-8 C₁₃H₁₂ClN₃O₂ 
• 25519-78-2 4-(4-fluorobenzoyl)piperidine hydrochloride 

Relevant articles and documents

Novel benzoylpiperidine-based stearoyl-CoA desaturase-1 inhibitors: Identification of 6-[4-(2-methylbenzoyl)piperidin-1-yl]pyridazine-3-carboxylic acid (2-hydroxy-2-pyridin-3-ylethyl)amide and its plasma triglyceride-lowering effects in Zucker fatty rats

Starting from a known piperazine-based SCD-1 inhibitor, we obtained more potent benzoylpiperidine analogs. Optimization of the structure of the benzoylpiperidine-based SCD-1 inhibitors resulted in the identification of 6-[4-(2-methylbenzoyl)piperidin-1-yl]pyridazine-3-carboxylic acid (2-hydroxy-2-pyridin-3-yl-ethyl)amide (24) which showed strong inhibitory activity against both human and murine SCD-1. In addition, this compound exhibited good oral bioavailability and demonstrated plasma triglyceride lowering effects in Zucker fatty rats in a dose-dependent manner after a 7-day oral administration (qd).