25519-78-2

Basic information

• Product Name: 4-(4-Fluorobenzoyl)piperidine hydrochloride
• Synonyms: 4-[(4-fluorophenyl)carbonyl]piperidine hydrochloride;(4-fluorophenyl)-4-piperidinylMethanone Hydrochloride;p-Fluorophenyl 4-Piperidinyl Ketone Hydrochloride;(4-Fluorophenyl)-4-piperidinyl-Methanone HCl;4-(4-FLUOROBENZOYL)PIPERIDINE HCL;4-(4'-FLUOROBENZOYL)PIPERIDINE HYDROCHLORIDE;4-(4-FLUOROBENZOYL)PIPERIDINE HYDROCHLORIDE;4-(P-FLUOROBENZOYL)PIPERIDINE HYDROCHLORIDE
• CAS NO: 25519-78-2
• Molecular Formula: C12H15ClFNO
• Molecular Weight: 243.71
• EINECS: 247-070-0
• Product Categories: Intermediates & Fine Chemicals;Pharmaceuticals;Benzene series;Piperazine;Aromatics;Heterocycles
• Mol File: 25519-78-2.mol
• Article Data: 5

Chemical Properties

• Melting Point: 222-224°C
• Boiling Point: 323.2 °C at 760 mmHg
• Flash Point: 149.3 °C
• Appearance: /
• Density: 1.31g/cm3 at 20℃
• Vapor Pressure: 0.000266mmHg at 25°C
• Storage Temp.: Inert atmosphere,Room Temperature
• Solubility: DMSO (Slightly), Water (Slightly)
• Sensitive: Hygroscopic
• CAS DataBase Reference: 4-(4-Fluorobenzoyl)piperidine hydrochloride(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(4-Fluorobenzoyl)piperidine hydrochloride(25519-78-2)
• EPA Substance Registry System: 4-(4-Fluorobenzoyl)piperidine hydrochloride(25519-78-2)

Safety Data

• Hazard Codes: Xi,C,Xn
• Statements: 36/37/38-20/21/22-22
• Safety Statements: 26-36/37/39-22
• HazardClass: IRRITANT, MOISTURE SENSITIVE, CO
• Hazardous Substances Data: 25519-78-2(Hazardous Substances Data)

Usage

Description

4-(4-Fluorobenzoyl)piperidine hydrochloride is a chemical compound belonging to the class of piperidine derivatives. It is characterized by the presence of a fluorobenzoyl group attached to the piperidine ring, which contributes to its unique chemical and pharmacological properties.

Uses

Used in Pharmaceutical Industry:
4-(4-Fluorobenzoyl)piperidine hydrochloride is used as an intermediate compound for the synthesis of various pharmaceutical agents. Its structural features make it a valuable building block in the development of new drugs with potential therapeutic applications.
Used in Antiarrhythmic Preparation:
In the field of cardiology, 4-(4-Fluorobenzoyl)piperidine hydrochloride is utilized as a key component in the preparation of antiarrhythmic drugs. These medications are designed to regulate abnormal heart rhythms, providing relief and improving the overall cardiac function.
Used in Circulatory Disease Treatment:
4-(4-Fluorobenzoyl)piperidine hydrochloride is also employed in the development of α1-adrenoceptor and S2-receptor antagonists, which are crucial in the treatment of circulatory diseases. These antagonists help in managing blood pressure, blood flow, and other related conditions, contributing to the overall improvement of cardiovascular health.

InChI:InChI=1/C12H14FNO.ClH/c13-11-3-1-9(2-4-11)12(15)10-5-7-14-8-6-10;/h1-4,10,14H,5-8H2;1H

Upstream product

• 59084-16-1 1-acetylpiperidine-4-carbonyl chloride 
• 160296-40-2 tert-butyl 1-[4-(4-fluorobenzoyl)piperidin-1-yl]carboxylate 
• 25519-77-1 1-(4-(4-fluorobenzoyl)piperidin-1-yl)ethanone 

Downstream Products

• 160296-40-2 tert-butyl 1-[4-(4-fluorobenzoyl)piperidin-1-yl]carboxylate 
• 1107014-53-8 C₂₅H₂₅FN₄O₃ 
• 1352724-59-4 (4-Fluorophenyl)(3'-hydroxy-[1,4'-bipiperidin]-4-yl)methanone 
• 1352724-63-0 (1'-(4-Fluorobenzyl)-3'-hydroxy-[1,4'-bipiperidin]-4-yl)(4-fluorophenyl)methanone 
• 1352724-55-0 1'-Benzoyl-4-(4-fluorobenzoyl)-[1,4'-bipiperidin]-3'-yl acetate 
• 132332-35-5 2,3-dihydro-6-phenyl-7H-oxazolo<3,2-a>pyrimidin-7-one 
• 132545-61-0 1-<2-<4-(4-fluorobenzoyl)piperidin-1-yl>ethyl>-5-phenyl-2,4(1H,3H)-pyrimidinedione hydrochloride hemihydrate 
• 55695-54-0 2-(p-fluorophenyl)-2-{3-[4-(p-fluoro-α-hydroxybenzyl)piperidino]propyl}-1,3-dioxolane 
• 38077-12-2 4-(p-fluoro-α-hydroxybenzyl)-1-[3-(p-fluorobenzoyl)propyl]piperidine 
• 75444-65-4 pirenperone 
• 74050-98-9 ketanserine 
• 56346-57-7 (4-fluorophenyl)-piperidin-4-ylmethanone 
• 83846-83-7 ketanserin tartrate 
• 698973-98-7 (4-fluorophenyl)(1-((2-phenyl-1H-imidazol-4-yl)methyl)piperidin-4-yl)methanone 

Relevant articles and documents

Novel benzoylpiperidine-based stearoyl-CoA desaturase-1 inhibitors: Identification of 6-[4-(2-methylbenzoyl)piperidin-1-yl]pyridazine-3-carboxylic acid (2-hydroxy-2-pyridin-3-ylethyl)amide and its plasma triglyceride-lowering effects in Zucker fatty rats

Starting from a known piperazine-based SCD-1 inhibitor, we obtained more potent benzoylpiperidine analogs. Optimization of the structure of the benzoylpiperidine-based SCD-1 inhibitors resulted in the identification of 6-[4-(2-methylbenzoyl)piperidin-1-yl]pyridazine-3-carboxylic acid (2-hydroxy-2-pyridin-3-yl-ethyl)amide (24) which showed strong inhibitory activity against both human and murine SCD-1. In addition, this compound exhibited good oral bioavailability and demonstrated plasma triglyceride lowering effects in Zucker fatty rats in a dose-dependent manner after a 7-day oral administration (qd).

Pyrroloazepine derivatives

Disclosed herein are pyrroloazepine derivatives, which are useful as therapeutics for circulatory diseases, represented by the following formula (I): STR1 wherein R means a hydrogen atom, a linear or branched C1-6 alkyl group or a C7-10 aralkyl group, A denotes a linear or branched C2-10 alkylene, alkenylene or alkynylene group, Z stands for O, NOR1 or NOCOR5 in which R1 and R5 is a hydrogen atom or an alkyl, aryl or aralkyl group, and Y means a particular piperidinyl or pyrrolidinyl group; and salts thereof. Their preparation processes are also disclosed.

Benzoylpiperidylalkylindoles

New benzoylpiperidylalkylindoles and related compounds possessing tranquilizing, anti-hypertensive and analgesic properties and a process for the preparation thereof are described.