111136-67-5Relevant articles and documents
Stereoselectivity of an ω-transaminase-mediated amination of 1,3-dihydroxy-1-phenylpropane-2-one
Smithies, Kirsty,Smith, Mark E.B.,Kaulmann, Ursula,Galman, James L.,Ward, John M.,Hailes, Helen C.
experimental part, p. 570 - 574 (2009/09/05)
The stereoselectivity of a recently isolated ω-transaminase from Chromobacterium violaceum in the amination of 1,3-dihydroxy-1-phenylpropan-2-one has been determined. The enzyme is not enantioselective towards a racemic mixture of 1,3-dihydroxy-1-phenylpr
Stereoselective synthesis of chloramphenicol from D-serine
Veeresa,Datta, Apurba
, p. 8503 - 8004 (2007/10/03)
An efficient synthesis of the widely used antibiotic chloramphenicol (1) is described. The key step in the synthesis involves chelation-controlled addition of phenylmagnesium bromide to a suitably protected D-serinal derivative, affording the pivotal D-threo 1,2-amino alcohol intermediate 3 in a highly stereoselective manner.