217661-64-8

Basic information

• Product Name: Acetic acid (1R,2R)-3-acetoxy-2-tert-butoxycarbonylamino-1-phenyl-propyl ester
• Synonyms: Acetic acid (1R,2R)-3-acetoxy-2-tert-butoxycarbonylamino-1-phenyl-propyl ester
• CAS NO: 217661-64-8
• Molecular Weight: 351.4
• Mol File: 217661-64-8.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: Acetic acid (1R,2R)-3-acetoxy-2-tert-butoxycarbonylamino-1-phenyl-propyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Acetic acid (1R,2R)-3-acetoxy-2-tert-butoxycarbonylamino-1-phenyl-propyl ester(217661-64-8)
• EPA Substance Registry System: Acetic acid (1R,2R)-3-acetoxy-2-tert-butoxycarbonylamino-1-phenyl-propyl ester(217661-64-8)

Safety Data

• Hazardous Substances Data: 217661-64-8(Hazardous Substances Data)

Upstream product

• 185692-85-7 tert-butyl (S)-1-(tert-butyldimethylsilyloxy)-3-hydroxypropan-2-yl carbamate 
• 217661-62-6 [(1R,2R)-1-(tert-Butyl-dimethyl-silanyloxymethyl)-2-hydroxy-2-phenyl-ethyl]-carbamic acid tert-butyl ester 
• 108-24-7 acetic anhydride 
• 1009093-14-4 ((1R,2R)-2-hydroxy-1-hydroxymethyl-2-phenylethyl)carbamic acid tert-butyl ester 

Downstream Products

• 56-75-7 chloramphenicol 
• 119-62-0 (1R,2R)-2-Amino-1-(4-nitrophenyl)-1,3-propanediol 
• 111136-67-5 (1R,2R)-2-acetamido-1-phenylpropane-1,3-diyl diacetate 
• 51259-82-6 (1R,2R)-1,3-diacetoxy-2-acetylamino-1-(4-nitro-phenyl)-propane 
• 439797-74-7 (1R,2R)-1,3-diacetoxy-2-amino-1-phenyl-propane 

Relevant articles and documents

Stereoselective synthesis of chloramphenicol from D-serine

An efficient synthesis of the widely used antibiotic chloramphenicol (1) is described. The key step in the synthesis involves chelation-controlled addition of phenylmagnesium bromide to a suitably protected D-serinal derivative, affording the pivotal D-threo 1,2-amino alcohol intermediate 3 in a highly stereoselective manner.