111256-83-8

Basic information

• Product Name: 4‐[4‐(dimethylamino)phenyl]‐4,5‐dihydro‐3H‐1,2,4‐triazole‐3,5‐dione
• Synonyms: 4‐[4‐(dimethylamino)phenyl]‐4,5‐dihydro‐3H‐1,2,4‐triazole‐3,5‐dione
• CAS NO: 111256-83-8
• Molecular Weight: 218.215
• Mol File: 111256-83-8.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 351.9±44.0 °C(Predicted)
• Density: 1.36±0.1 g/cm3(Predicted)
• CAS DataBase Reference: 4‐[4‐(dimethylamino)phenyl]‐4,5‐dihydro‐3H‐1,2,4‐triazole‐3,5‐dione(CAS DataBase Reference)
• NIST Chemistry Reference: 4‐[4‐(dimethylamino)phenyl]‐4,5‐dihydro‐3H‐1,2,4‐triazole‐3,5‐dione(111256-83-8)
• EPA Substance Registry System: 4‐[4‐(dimethylamino)phenyl]‐4,5‐dihydro‐3H‐1,2,4‐triazole‐3,5‐dione(111256-83-8)

Safety Data

• Hazardous Substances Data: 111256-83-8(Hazardous Substances Data)

Usage

Description

4‐[4‐(dimethylamino)phenyl]‐4,5‐dihydro‐3H‐1,2,4‐triazole‐3,5‐dione, also known as DAPTAD, is a Cookson-type reagent with a unique chemical structure that features a dimethylamino group attached to a phenyl ring, connected to a 1,2,4-triazole-3,5-dione moiety. 4‐[4‐(dimethylamino)phenyl]‐4,5‐dihydro‐3H‐1,2,4‐triazole‐3,5‐dione is known for its high sensitivity and specificity in chemical reactions.

Uses

Used in Vitamin D3 Analysis:
4‐[4‐(dimethylamino)phenyl]‐4,5‐dihydro‐3H‐1,2,4‐triazole‐3,5‐dione is used as a derivatization agent for vitamin D3, specifically for the preparation of 25(OH)D3 samples in liquid chromatography-tandem mass spectrometry (LC-MS). It enhances the detection and quantification of vitamin D3 levels in biological samples, providing accurate and reliable results for assessing vitamin D status in various applications.

Upstream product

• 883455-55-8 4‐(4'‐dimethylaminophenyl)‐1,2,4‐triazolidine‐3,5‐dione 
• 112667-72-8 1-ethoxycarbonyl-4-(4'-dimethylaminophenyl)semicarbazide 
• 16315-59-6 N,N-dimethylaminophenyl isocyanate 
• 70843-95-7 azido(4-(dimethylamino)phenyl)methanone 
• 4755-50-4 4-(dimethylamino)benzoyl chloride 

Relevant articles and documents

A novel Cookson-type reagent for enhancing sensitivity and specificity in assessment of infant vitamin D status using liquid chromatography/tandem mass spectrometry

Rationale 25-Hydroxyvitamin D3 [25(OH)D3] is the best-established indicator of vitamin D status. 4-Phenyl-1,2,4-triazoline-3,5- dione (PTAD), a representative Cookson-type reagent, has often been employed for enhancing the sensitivit

METHOD FOR PRODUCING SOLID TRIAZOLINEDIONE COMPOUND, SOLID TRIAZOLINEDIONE COMPOUND, AND METHOD FOR PRODUCING TRIAZOLINEDIONE COMPOUND

Provided are a method for separating a DAPTAD-containing triazolinedione compound in solid form from a reaction solution, a separated solid triazolinedione compound, and a novel method for producing a triazolinedione compound. A triazolinedione solution in which a DAPTAD-containing triazolinedione compound is dissolved is brought into contact with a C5-15 hydrocarbon-based poor solvent to obtain a solid triazolinedione compound. Also, a triazolinedione compound is oxidized using an oxidizing agent that does not produce acid as a byproduct to obtain a triazolinedione compound.