111479-09-5

Basic information

• Product Name: 2-(4-methoxyphenoxy)propanoyl chloride
• Synonyms: 2-(4-methoxyphenoxy)propanoyl chloride;propanoyl chloride, 2-(4-methoxyphenoxy)-
• CAS NO: 111479-09-5
• Molecular Formula: C10H11ClO3
• Molecular Weight: 214.64554
• Mol File: 111479-09-5.mol
• Article Data: 4

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2-(4-methoxyphenoxy)propanoyl chloride(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(4-methoxyphenoxy)propanoyl chloride(111479-09-5)
• EPA Substance Registry System: 2-(4-methoxyphenoxy)propanoyl chloride(111479-09-5)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 111479-09-5(Hazardous Substances Data)

Usage

General Description

2-(4-methoxyphenoxy)propanoyl chloride is a chemical compound consisting of a propanoyl chloride group attached to a 4-methoxyphenoxy moiety. It is commonly utilized in organic synthesis reactions as a versatile acylation reagent. 2-(4-methoxyphenoxy)propanoyl chloride undergoes various chemical reactions, such as acylation and nucleophilic substitution, and is commonly used as an intermediate in the synthesis of pharmaceuticals and agrochemicals. Additionally, 2-(4-methoxyphenoxy)propanoyl chloride is known for its potential use as a building block in the production of polymers and high-performance materials. Overall, this chemical compound serves as a valuable reagent in various organic reactions and has applications in several different industries.

Upstream product

• 13794-15-5 2-(4-methoxyphenoxy)propanoic acid 
• 106939-42-8 (S)-7,8-difluoro-3,4-dihydro-3-methyl-2H-1,4-benzoxazine 
• 92818-05-8 2-(4'-methoxyphenoxy)propanoic acid chloride 
• 150-76-5 4-methoxy-phenol 

Downstream Products

• 815622-52-7 2-(4-methoxyphenoxy)propanamide 
• 4276-73-7 2-(4-nethoxyphenoxy)propionic acid 
• 4276-74-8 (S)-2-(4-nethoxyphenoxy)propionic acid 
• 92817-73-7 (Z)-1-(4'-methyl-2',6'-di-tert-butylphenoxy)-1-(4-methoxyphenoxy)-1-((trimethylsilyl)oxy)propene 
• 92817-74-8 (E)-1-(4'-methyl-2',6'-di-tert-butylphenoxy)-1-(4-methoxyphenoxy)-1-((trimethylsilyl)oxy)propene 
• 92817-79-3 4'-methyl-2',6'-di-tert-butylphenyl (2RS,3RS)-2,4-dimethyl-3-hydroxy-2-(4-methoxyphenoxy)hexanoate 
• 92817-80-6 4'-methyl-2',6'-di-tert-butylphenyl (2RS,3SR)-2,4-dimethyl-3-hydroxy-2-(4-methoxyphenoxy)hexanoate 
• 92817-81-7 4'-methyl-2',6'-di-tert-butylphenyl (2RS,3SR)-3-hydroxy-2-methyl-2-(4-methoxyphenoxy)-3-benzenepropanoate 

Relevant articles and documents

Mutual Kinetic Resolution of Racemic 3,4-Dihydro-3-methyl-2H-[1,4]benzoxazines with Acyl Chlorides of Racemic O-Phenyllactic Acids and DFT Modelling of Transition States

The effect of the electronic nature of the para substituent on the aromatic ring of 2-aryloxypropionyl chlorides on the stereochemical outcome of the acylation of 3,4-dihydro-3-methyl-2H-[1,4]benzoxazine and its 7,8-difluoro-containing analogue has been studied. The geometries of the diastereoisomeric transition states and the corresponding Gibbs free enthalpies of activation were determined through DFT calculations at the COSMO-CH2Cl2-B3LYP-D3-gCP/def2-TZVP (or def2-SVP)//B3LYP-D3-gCP/def2-SVP level of theory. It has been found that a low-cost quantum chemical calculation at a chosen level of theory describes well the quantitative dependence of the selectivity of acylation on the structures of the reagents. The obtained results indicate that aromatic interactions between the reagents play a significant role in the process of stereodifferentiation, ensuring high selectivity of the acylation of benzoxazines with 2-aryloxyacyl chlorides.

PRECURSOR COMPOUNDS OF SWEET TASTE RECEPTOR ANTAGONISTS FOR THE PREVENTION OR TREATMENT OF DISEASE

A description is given of precursor compounds of sweet taste receptor antagonists for the prevention or treatment of disease, in particular for the prevention or treatment of Type 2 diabetes. A description is also given of uses of these precursor compound