92818-05-8

Basic information

• Product Name: 2-(4'-methoxyphenoxy)propanoic acid chloride
• Synonyms: 2-(4'-methoxyphenoxy)propanoic acid chloride
• CAS NO: 92818-05-8
• Molecular Weight: 214.649
• Mol File: 92818-05-8.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: 2-(4'-methoxyphenoxy)propanoic acid chloride(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(4'-methoxyphenoxy)propanoic acid chloride(92818-05-8)
• EPA Substance Registry System: 2-(4'-methoxyphenoxy)propanoic acid chloride(92818-05-8)

Safety Data

• Hazardous Substances Data: 92818-05-8(Hazardous Substances Data)

Upstream product

• 13794-15-5 2-(4-methoxyphenoxy)propanoic acid 
• 150-76-5 4-methoxy-phenol 

Downstream Products

• 4276-73-7 2-(4-nethoxyphenoxy)propionic acid 
• 4276-74-8 (S)-2-(4-nethoxyphenoxy)propionic acid 
• 111479-09-5 2-(4-methoxyphenoxy)propionyl chloride 
• 111479-09-5 2-(4-methoxyphenoxy)propionyl chloride 
• 815622-52-7 2-(4-methoxyphenoxy)propanamide 
• 92817-73-7 (Z)-1-(4'-methyl-2',6'-di-tert-butylphenoxy)-1-(4-methoxyphenoxy)-1-((trimethylsilyl)oxy)propene 
• 92817-74-8 (E)-1-(4'-methyl-2',6'-di-tert-butylphenoxy)-1-(4-methoxyphenoxy)-1-((trimethylsilyl)oxy)propene 
• 92817-79-3 4'-methyl-2',6'-di-tert-butylphenyl (2RS,3RS)-2,4-dimethyl-3-hydroxy-2-(4-methoxyphenoxy)hexanoate 
• 92817-80-6 4'-methyl-2',6'-di-tert-butylphenyl (2RS,3SR)-2,4-dimethyl-3-hydroxy-2-(4-methoxyphenoxy)hexanoate 
• 92817-81-7 4'-methyl-2',6'-di-tert-butylphenyl (2RS,3SR)-3-hydroxy-2-methyl-2-(4-methoxyphenoxy)-3-benzenepropanoate 
• 92817-70-4 4'-methyl-2,6-di-tert-butylphenyl 2-(4methoxyphenoxy)propanoate 

Relevant articles and documents

Mutual Kinetic Resolution of Racemic 3,4-Dihydro-3-methyl-2H-[1,4]benzoxazines with Acyl Chlorides of Racemic O-Phenyllactic Acids and DFT Modelling of Transition States

The effect of the electronic nature of the para substituent on the aromatic ring of 2-aryloxypropionyl chlorides on the stereochemical outcome of the acylation of 3,4-dihydro-3-methyl-2H-[1,4]benzoxazine and its 7,8-difluoro-containing analogue has been studied. The geometries of the diastereoisomeric transition states and the corresponding Gibbs free enthalpies of activation were determined through DFT calculations at the COSMO-CH2Cl2-B3LYP-D3-gCP/def2-TZVP (or def2-SVP)//B3LYP-D3-gCP/def2-SVP level of theory. It has been found that a low-cost quantum chemical calculation at a chosen level of theory describes well the quantitative dependence of the selectivity of acylation on the structures of the reagents. The obtained results indicate that aromatic interactions between the reagents play a significant role in the process of stereodifferentiation, ensuring high selectivity of the acylation of benzoxazines with 2-aryloxyacyl chlorides.

PRECURSOR COMPOUNDS OF SWEET TASTE RECEPTOR ANTAGONISTS FOR THE PREVENTION OR TREATMENT OF DISEASE

A description is given of precursor compounds of sweet taste receptor antagonists for the prevention or treatment of disease, in particular for the prevention or treatment of Type 2 diabetes. A description is also given of uses of these precursor compound