111524-87-9

Basic information

• Product Name: L-Phenylalanine, (2R)-N-[(9H-fluoren-9-ylmethoxy)carbonyl]-2-phenylglycyl-, methyl ester
• CAS NO: 111524-87-9
• Molecular Formula: C33H30N2O5
• Molecular Weight: 534.612
• Mol File: 111524-87-9.mol
• Article Data: 17

Chemical Properties

• CAS DataBase Reference: L-Phenylalanine, (2R)-N-[(9H-fluoren-9-ylmethoxy)carbonyl]-2-phenylglycyl-, methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: L-Phenylalanine, (2R)-N-[(9H-fluoren-9-ylmethoxy)carbonyl]-2-phenylglycyl-, methyl ester(111524-87-9)
• EPA Substance Registry System: L-Phenylalanine, (2R)-N-[(9H-fluoren-9-ylmethoxy)carbonyl]-2-phenylglycyl-, methyl ester(111524-87-9)

Safety Data

• Hazardous Substances Data: 111524-87-9(Hazardous Substances Data)

Upstream product

• 63-91-2 L-phenylalanine 
• 111524-95-9 N-Fmoc-D-phenylglycine 
• 111524-97-1 Fmoc-D-Phg-Cl 
• 7524-50-7 methyl (2S)-2-amino-3-phenylpropanoate hydrochloride 
• 2577-90-4 methyl (2S)-2-amino-3-phenylpropanoate 
• 329309-03-7 Fmoc-(D)Phg-N₃ 

Downstream Products

• 111524-94-8 H-D-Phg-Phe-OMe*CF₃CO₂H 
• 94778-64-0 (S)-N-((R)-2-phenyl-2-N-(tert-butoxycarbonyl)glycinyl)phenylalanine methyl ester 

Relevant articles and documents

Synthesis of peptides employing protected-amino acid halides mediated by commercial anion exchange resin

Coupling of protected-amino acid halides (chloride, fluoride) mediated by commercial anion exchange resin for the solution phase synthesis of peptides is described. The reaction was carried out in an organic medium, circumventing the use of an organic base or an inorganic base. The coupling is fast, clean and racemization free. The anion exchange resin functions as a solid-phase basic scavenger, soaking up the HCl produced and allowing the amine to react. The method is extended for the coupling of sterically hindered α,α,- dialkylamino acids. Graphical Abstract: [Figure not available: see fulltext.]

Peptide Bond Formation via Nα-Protected Diacyldiselenides

Abstract: A simple, straightforward, for the peptide bond formation employing corresponding carboxylic acids and amines derived from amino acids via Nα-protected diacyldiselenide is delineated. The key step of the synthesis is the in situ gener

Synthesis of selenoxo peptides and oligoselenoxo peptides employing LiAlHSeH

Synthesis of selenoxo peptides by the treatment of Nα- protected peptide esters with a combination of PCl5 and LiAlHSeH is delineated. The method is simple, high-yielding, and free from racemization. Thus obtained selenoxo peptides are used as units for N-terminal chain extension through Nα-deprotection/coupling to yield peptide-selenoxo peptide hybrids. Multiple selenation is demonstrated by conversion of two peptide bonds of tripeptides into selenoxo peptide bonds. Amino acid derived arylamides are also converted into aryl selenoamides. C6H 5-CSeNH-Val-OMe 8f is obtained as single crystal, and its structure was determined through X-ray diffraction study.