111810-68-5

Basic information

• Product Name: 3-hydroxypyrrolidine hydrochloride
• CAS NO: 111810-68-5
• Molecular Weight: 123.582
• Mol File: 111810-68-5.mol
• Article Data: 18

Chemical Properties

• CAS DataBase Reference: 3-hydroxypyrrolidine hydrochloride(CAS DataBase Reference)
• NIST Chemistry Reference: 3-hydroxypyrrolidine hydrochloride(111810-68-5)
• EPA Substance Registry System: 3-hydroxypyrrolidine hydrochloride(111810-68-5)

Safety Data

• Hazardous Substances Data: 111810-68-5(Hazardous Substances Data)

Upstream product

• 52334-81-3 2-chloro-5-trifluoromethylpyridine 
• 101469-91-4 (3S)-1-benzyl-3-hydroxypyrrolidine-2,5-dione 
• 98-59-9 p-toluenesulfonyl chloride 
• 51-35-4 4R-4-hydroxyproline 
• 130680-56-7 (3R)-N-acetyl-3-(tert-butyldimethylsilyloxy)propylamine 
• 101469-92-5 (S)-3-hydroxy-pyrrolidine-1-carboxylic acid tert-butyl ester 
• 127913-44-4 (S)-4-chloro-3-hydroxy butyronitrile 
• 109431-87-0 (R)-tert-butyl 3-hydroxypyrrolidine-1-carboxylate 

Downstream Products

• 1429414-83-4 5-(3-hydroxypyrrolidin-1-yl)picolinonitrile 
• 1315054-87-5 C₇H₁₄N₂O₂ 
• 1315054-87-5 C₇H₁₄N₂O₂ 
• 103057-44-9 N-(tert-butoxycarbonyl)-3-hydroxypyrrolidine 

Relevant articles and documents

Hydrogenation of chiral nitrile on highly ordered mesoporous carbon-supported Pd catalysts

A highly ordered mesoporous carbon (C-SBA-15 and C-SBA-16) was synthesized by nanocasting method using its corresponding mesoporous silica (SBA-15 and SBA-16) as a template. The obtained porous carbons have high surface areas, large pore volume and a narrow pore size distribution. The N2-adsorption data for C-SBA-15 have provided the BET area of 2029 m2 g-1 and the total pore volume of 1.7 cm3 g-1, and 1637 m2 g-1 and 1.1 cm3 g-1 for C-SBA-16, respectively. The palladium metal impregnated carbon catalysts were employed in the synthesis of (S)-3-pyrrolidinol from chiral (S)-4-chloro-3-hydroxybutyronitrile, and a high yield to (S)-3-pyrrolidinol-salt was obtained by using 1 wt% Pd/C-SBA-16. It was investigated that the well-dispersed Pd metals in the confined mesopores are efficient for the hydrogenation of cyano groups to amine.

COMPOUNDS

Disclosed are novel compounds that inhibit LRRK2 kinase activity, processes for their preparation, compositions containing them and their use in the treatment of or prevention of diseases characterized by LRRK2 kinase activity, for example Parkinson's disease, Alzheimer's disease and amyotrophic lateral sclerosis(ALS).

POLYCYCLIC DERIVATIVES, PREPARATION PROCESS AND PHARMACEUTICAL USE THEREOF

Disclosed in the present invention are polycyclic derivatives as represented by general formula (I), the preparation method thereof, pharmaceutical compositions containing the derivatives and uses thereof as therapeutic agents, especially the GPR40 agonist and in preparation of drugs for treating diseases such as diabetes and metabolic disorders, etc., wherein each substituent in the general formula (I) has the same definition as in the description.