112066-67-8

Basic information

• Product Name: (R)-N-methyl-3-(2-methoxyphenoxy)-3-phenyl-1-propanamine
• Synonyms: (R)-N-methyl-3-(2-methoxyphenoxy)-3-phenyl-1-propanamine
• CAS NO: 112066-67-8
• Molecular Weight: 271.359
• Mol File: 112066-67-8.mol
• Article Data: 7

Chemical Properties

• CAS DataBase Reference: (R)-N-methyl-3-(2-methoxyphenoxy)-3-phenyl-1-propanamine(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-N-methyl-3-(2-methoxyphenoxy)-3-phenyl-1-propanamine(112066-67-8)
• EPA Substance Registry System: (R)-N-methyl-3-(2-methoxyphenoxy)-3-phenyl-1-propanamine(112066-67-8)

Safety Data

• Hazardous Substances Data: 112066-67-8(Hazardous Substances Data)

Upstream product

• 114133-37-8 (S)-N-methyl-3-amino-1-phenyl-1-propanol 
• 90-05-1 2-methoxy-phenol 
• 1453857-68-5 (S)-3-(tert-butyldimethylsilyloxy)-N-methyl-3-phenylpropan-1-amine 
• 1453857-66-3 (S)-3-(tert-butyldimethylsilyloxy)-3-phenylpropyl methanesulfonate 
• 1453857-64-1 (S)-3-(tert-butyldimethylsilylyloxy)-3-phenylpropan-1-ol 
• 130115-07-0 (R)-2-(t-butyldimethylsilyloxy)-2-phenylacetaldehyde 
• 120390-75-2 (R)-(+)-α-<(tert-butyldimethylsilyl)oxy>-benzeneacetonitrile 
• 10020-96-9 (R)-Mandelonitrile 
• 100-52-7 benzaldehyde 
• 142037-19-2 Chloro-acetic acid (S)-3-chloro-1-phenyl-propyl ester 
• 100306-33-0 (1R)-3-chloro-1-phenylpropanol 
• 141987-54-4 1-Phenyl-3-chlor-propyl-monochloracetat 
• 293322-40-4 3-Cloro-1-phenylpropyl butanoate 
• 18776-12-0 3-chloro-1-phenyl-propan-1-ol 

Relevant articles and documents

Chemoenzymatic synthesis of the non-tricyclic antidepressants Fluoxetine, Tomoxetine and Nisoxetine

3-Chloro-1-phenylpropan-1-ol and the corresponding butanoate, 3-chloro-1-phenyl-1-propyl butanoate, were kinetically resolved using lipase B from Candida antarctica catalysis by transesterification and hydrolysis respectively. The resulting chiral building blocks (S)- and (R)-3-chloro-1-phenylpropanol were converted into both enantiomers of the antidepressant drugs, Fluoxetine, Tomoxetine and Nisoxetine. The Royal Society of Chemistry 2000.

A method for preparing optically active 3-amino-1-phenylpropanol derivatives as an intermediate and a method for preparing optically active pharmaceutical products using the same

The present invention relates to a method for preparing a 3-amino-1-phenylpropanol derivative having (R) or (S) optical activity with 80% or more of an enantiomeric excess (ee), which includes a step of performing an asymmetric reduction reaction in the presence of a spiroborate ester catalyst and a hydrogen donor. The invention also relates to a method for preparing an optically active pharmaceutical product, which includes a step of preparing a (R)- or (S)-3-amino-1-phenylpropanol derivative, that is an intermediate, by using the catalyst.(AA) 3-amino-1-phenylpropanol(BB) Tomoxetine(CC) Nisoxetine(DD) FluoxetineCOPYRIGHT KIPO 2016

Synthesis and C-11 labeling of three potent norepinephrine transporter selective ligands ((R)-nisoxetine, lortalamine, and oxaprotiline) for comparative PET studies in baboons

Three potent antidepressants, (R)-nisoxetine, lortalamine, and oxaprotiline, with high affinity and high selectivity for the norepinephrine transporter (NET) were synthesized and radiolabeled with C-11 via [ 11C]methylation. The reference compo