1453857-66-3

Basic information

• Product Name: (S)-3-(tert-butyldimethylsilyloxy)-3-phenylpropyl methanesulfonate
• Synonyms: (S)-3-(tert-butyldimethylsilyloxy)-3-phenylpropyl methanesulfonate
• CAS NO: 1453857-66-3
• Molecular Weight: 344.547
• Mol File: 1453857-66-3.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (S)-3-(tert-butyldimethylsilyloxy)-3-phenylpropyl methanesulfonate(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-3-(tert-butyldimethylsilyloxy)-3-phenylpropyl methanesulfonate(1453857-66-3)
• EPA Substance Registry System: (S)-3-(tert-butyldimethylsilyloxy)-3-phenylpropyl methanesulfonate(1453857-66-3)

Safety Data

• Hazardous Substances Data: 1453857-66-3(Hazardous Substances Data)

Upstream product

• 1453857-64-1 (S)-3-(tert-butyldimethylsilylyloxy)-3-phenylpropan-1-ol 
• 124-63-0 methanesulfonyl chloride 
• 130115-07-0 (R)-2-(t-butyldimethylsilyloxy)-2-phenylacetaldehyde 
• 120390-75-2 (R)-(+)-α-<(tert-butyldimethylsilyl)oxy>-benzeneacetonitrile 
• 10020-96-9 (R)-Mandelonitrile 
• 100-52-7 benzaldehyde 

Downstream Products

• 54910-89-3 (R)-fluoxetine 
• 105314-52-1 (R)-tomoxetine 
• 112066-67-8 (R)-N-methyl-3-(2-methoxyphenoxy)-3-phenyl-1-propanamine 
• 114133-37-8 (S)-N-methyl-3-amino-1-phenyl-1-propanol 
• 1453857-68-5 (S)-3-(tert-butyldimethylsilyloxy)-N-methyl-3-phenylpropan-1-amine 

Relevant articles and documents

Chemoenzymatic asymmetric synthesis of fluoxetine, atomoxetine, nisoxetine, and duloxetine

The asymmetric synthesis of two well-known anti-depressant drugs, fluoxetine and duloxetine has been accomplished in a chemoenzymatic manner. The main highlight of the synthesis is the enantioselective cyanohydrin formation by a plant (R)-HNL (hydroxynitrile lyase). The enantiopure cyanohydrins are then synthetically manipulated into the above two drug molecules and two of their structural analogues, atomoxetine and nisoxetine.