112110-16-4Relevant articles and documents
Preparation method of dimethyl 5-methoxymethyl-2, 3-pyridinedicarboxylate
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Paragraph 0097-0098; 0103-0104; 0109-0110, (2021/06/26)
The invention relates to the field of pesticide synthesis, and discloses a preparation method of dimethyl 5-methoxymethyl-2, 3-pyridinedicarboxylate. The method comprises the steps of 1) in the presence of alkali, carrying out transesterification on dimethyl 5-methyl-2, 3-pyridinedicarboxylate and methanol; 2) in the presence of an organic solvent, carrying out bromination reaction on the dimethyl 5-methyl-2, 3-pyridinedicarboxylate and a brominating agent to obtain a reaction product containing the dimethyl 5-methyl-2, 3-pyridinedicarboxylate, a monobromide, a dibromide and a tribromide; 3) performing quaternary ammonium salinization on the monobromide contained in the reaction product, and separating the monobromide from the reaction product subjected to quaternary ammonium salinization to obtain quaternary ammonium salt; and (4) enabling quaternary ammonium salt to be in contact with a sodium methoxide solution so as to obtain the dimethyl 5-methoxymethyl-2, 3-pyridinedicarboxylate. According to the method disclosed by the invention, few impurities are generated in the reaction process, and the steps are simple.
Microwave-assisted Diels-Alder reaction supported on graphite
Garrigues, Bernard,Laporte, Christian,Laurent, Regis,Laporterie, Andre,Dubac, Jacques
, p. 739 - 741 (2007/10/03)
The coupling of graphite (as a support) with microwaves (as an energy source), a new type of "dry reaction", was studied for some Diels-Alder reactions involving anthracene and azadienes. Graphite is responsible for a high-temperature gradient leading to increased reaction rates as compared to conventional procedures using a solvent. VCH Verlagsgesellschaft mbH, 1996.
Process for the preparation of pyridine-2,3-dicarboxylic acid derivatives
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, (2008/06/13)
A pyridine compound of formula I is prepared from a tetrahydropyridine compound of formula II in a single step or procedure under oxidising conditions. The R meanings are fully defined in the specification but preferably R1 and R3 represent hydrogen, R2, R11 and R12 represent alkyl, and R4 and R5 represent hydroxy or alkoxy or together represent -O- or -NR10- where R10 represents alkyl, cyanoalkyl, aminocarbonylalkyl or phenyl.