53636-65-0

Basic information

• Product Name: 5-Methylpyridine-2,3-dicarboxylic acid
• Synonyms: 5-Methylpyridine-2,3-dicarboxylic acid;(5-Methyl-2,3-pyridinedicarboxylic acid)
• CAS NO: 53636-65-0
• Molecular Formula: C₈H₇NO₄
• Molecular Weight: 181.15
• Mol File: 53636-65-0.mol
• Article Data: 11

Chemical Properties

• Boiling Point: 436.2oC at 760 mmHg
• Flash Point: 217.6oC
• Appearance: /
• Density: 1.460
• Vapor Pressure: 2.22E-08mmHg at 25°C
• Refractive Index: 1.61
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• PKA: 5.41±0.20(Predicted)
• CAS DataBase Reference: 5-Methylpyridine-2,3-dicarboxylic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 5-Methylpyridine-2,3-dicarboxylic acid(53636-65-0)
• EPA Substance Registry System: 5-Methylpyridine-2,3-dicarboxylic acid(53636-65-0)

Safety Data

• Hazardous Substances Data: 53636-65-0(Hazardous Substances Data)

Usage

InChI:InChI=1/C8H7NO4/c1-4-2-5(7(10)11)6(8(12)13)9-3-4/h2-3H,1H3,(H,10,11)(H,12,13)

Upstream product

• 75457-13-5 8-hydroxy-3-methylquinoline 
• 612-58-8 3-methylquinoline 
• 20668-26-2 3,6-dimethylquinoline 
• 7732-18-5 water 
• 112110-16-4 5-methyl-2,3-pyridinedicarboxylic acid dimethyl ester 
• 104098-48-8 imazapic 
• 105151-48-2 diethyl 5-methylpyridine-2,3-dicarboxylate 

Downstream Products

• 105151-48-2 diethyl 5-methylpyridine-2,3-dicarboxylate 
• 104098-48-8 imazapic 

Relevant articles and documents

Preparation method of nitrogen-containing aromatic dicarboxylic acid

The invention discloses a preparation method of nitrogen-containing aromatic dicarboxylic acid. The method includes: taking quinoline, isoquinoline, benzimidazole or benzotriazole and a derivative thereof as the raw materials, adopting oxone as the oxidant, employing a metal salt as the catalyst and using inorganic acid as the medium, adding a phase transfer reagent, and carrying out reaction to obtain nitrogen-containing aromatic dicarboxylic acid. The reagents used by the method are high in stability, convenient for transportation and storage, the operation is simple, the conditions are easily controllable, and the price is low, at the same time, the catalytic effect is good, the yield is high, and waste liquid treatment is easy, therefore the method is convenient for industrial large-scale production.

Recovery method and production method of substituted or unsubstituted 2,3-pyridine dicarboxylic acid

The present invention relates to the field of pyridine dicarboxylic acids, and discloses a recovery method and a production method of substituted or unsubstituted 2,3-pyridine dicarboxylic acid. The recovery method comprises: (1) adding an extraction liquid to a solution containing substituted or unsubstituted 2,3-pyridine dicarboxylic acid represented by a formula (I) to obtain a raffinate phaseand an extraction phase; (2) adding an alkali solution to the extraction phase, adjusting the pH value to achieve an alkaline state, and carrying out oil-water separation to obtain an organic phase and an aqueous phase containing substituted or unsubstituted 2,3-pyridine dicarboxylic acid; and (3) adding an acid solution to the aqueous phase, adjusting the pH value to achieve an acidic state, carrying out standing layering, and filtering to obtain the substituted or unsubstituted 2,3-pyridine dicarboxylic acid represented by the formula (I), wherein in the formula (1), R1, R2 and R3 respectively and independently are H, C1-C4 alkyl, C1-C4 alkoxy, halogen, hydroxy, nitro or amino. According to the present invention, the recovery method can greatly improve the recovery rate, has good extraction effect, is simple and easy to perform, and is suitable for industrial production. The formula (1) is defined in the specification.

Method for the preparation of 2,3-pyridine-dicarboxylic acids and derivatives thereof

There is provided an improved process for the preparation of substituted and unsubstituted 2,3-pyridinedicarboxylic acids in significantly enhanced yield by the nitric acid oxidation of the appropriately substituted quinoline precursor in the presence of a catalytic amount of Manganese.