112192-04-8 Usage
Description
3-[4-(3,6-DIHYDRO-4-PHENYL-1(2H)-PYRIDINYL)BUTYL]-1H-INDOL-5-OL HYDROCHLORIDE, also known as Roxindole Hydrochloride, is a chemical compound with a complex structure that serves as a selective and potent presynaptic D-2 dopamine autoreceptor agonist. It plays a crucial role in modulating dopamine levels in the brain, which can have significant implications for various neurological conditions.
Uses
Used in Pharmaceutical Industry:
Roxindole Hydrochloride is used as a therapeutic agent for the treatment of Parkinson's disease. As a D-2 dopamine autoreceptor agonist, it helps to increase dopamine levels in the brain, which can alleviate the motor symptoms associated with Parkinson's disease, such as tremors, rigidity, and bradykinesia.
Additionally, due to its ability to modulate dopamine levels, Roxindole Hydrochloride may also have potential applications in the treatment of other neurological disorders characterized by dopamine imbalances, such as schizophrenia and addiction. However, further research is needed to fully understand its potential applications and efficacy in these areas.
Biological Activity
Dopamine D 2 autoreceptor agonist, with affinity for D 3 , D 4 and 5-HT 1 receptors (pK i values are 8.55, 8.93, 8.23, 9.42, 6.00 and 7.05 for human D 2 , D 3 , D 4 , 5-HT 1A , 5-HT 1B and 5-HT 1D receptors). Inhibits 5-HT uptake and is antidepressant in vivo .
Check Digit Verification of cas no
The CAS Registry Mumber 112192-04-8 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,1,2,1,9 and 2 respectively; the second part has 2 digits, 0 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 112192-04:
(8*1)+(7*1)+(6*2)+(5*1)+(4*9)+(3*2)+(2*0)+(1*4)=78
78 % 10 = 8
So 112192-04-8 is a valid CAS Registry Number.
InChI:InChI=1/C23H26N2O/c26-21-9-10-23-22(16-21)20(17-24-23)8-4-5-13-25-14-11-19(12-15-25)18-6-2-1-3-7-18/h1-3,6-7,9-11,16-17,24,26H,4-5,8,12-15H2
112192-04-8Relevant articles and documents
A straightforward synthetic approach for roxindole
Lange, Jos H. M.,De Jong, Johannes C.,Sanders, Hans J.,Visser, Geb M.,Kruse, Chris G.
, p. 1055 - 1056 (2007/10/03)
A concise synthetic approach to the dopamine autoreceptor agonist roxindole 1 has been devised. The key step in the novel route is the addition of succinic anhydride to 5-methoxyindolylmagnesium bromide, which circumvents the cumbersome construction of th
