cas 112192-04-8, 3-[4-(3,6-DIHYDRO-4-PHENYL-1(2H)-PYRIDINYL)BUTYL]-1H-INDOL-5-OL HYDROCHLORIDE | Articles data ｜lookchem

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112192-04-8

Articles about 112192-04-8Total 2 be found

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A straightforward synthetic approach for roxindole
A concise synthetic approach to the dopamine autoreceptor agonist roxindole 1 has been devised. The key step in the novel route is the addition of succinic anhydride to 5-methoxyindolylmagnesium bromide, which circumvents the cumbersome construction of th
Lange, Jos H. M.,De Jong, Johannes C.,Sanders, Hans J.,Visser, Geb M.,Kruse, Chris G.
p. 1055 - 1056
(2007/10/03)

Synthesis and dopaminergic activity of some 3-(1,2,3,6-tetrahydro-1- pyridylalkyl)indoles. A novel conformational model to explain structure- activity relationships
The synthesis and dopaminergic properties of a novel type of dopamine agonist is described. The number and kind of essential structural elements differ significantly from that of the rigid apomorphine-type dopamine agonists. Using standard molecular modeling techniques, a conformational model is developed proposing a U-shaped conformation which might be energetically preferred through aromatic π-π-interactions between both of the electron rich aromatic structural elements of this class of compounds. Superimposition of conformations of the lead compound 28 with apomorphine yields a novel model explaining the atypical structure-activity relationships found in this class of indolealkylamines.
Bottcher,Barnickel,Hausberg,Haase,Seyfried,Eiermann
p. 4020 - 4026
(2007/10/02)

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Chemical Properties

Boiling Point: 575.7°Cat760mmHg
Flash Point:302°C
Density: 1.173g/cm³
Solubility:DMSO (Slightly), Water (Slightly)
Storage Temp.:Desiccate at -20°C
Vapor Pressure: 7.46E-14mmHg at 25°C
PKA: 10.15±0.40(Predicted)
PSA: 39.26000
LogP: 4.92340

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