112193-75-6 Usage
Description
1,4,7,10-Tetraazacyclododecane-1,7-diacetic acid is a macrocyclic ligand that is known for its ability to form stable complexes with metal ions. It is also recognized as an impurity in Gadoteridol (G125900), a widely used MRI contrast chelating agent.
Uses
Used in Pharmaceutical Industry:
1,4,7,10-Tetraazacyclododecane-1,7-diacetic acid is used as a chelating agent for metal ions, particularly in the context of Gadoteridol (G125900), an MRI contrast agent. Its role in this application is crucial for enhancing the imaging capabilities of MRI scans by improving the contrast between different tissues.
Used in Medical Imaging:
1,4,7,10-Tetraazacyclododecane-1,7-diacetic acid is used as a component in MRI contrast agents for medical imaging. Its presence in Gadoteridol (G125900) contributes to the effectiveness of the contrast agent, allowing for clearer visualization of internal structures and aiding in the diagnosis of various medical conditions.
Check Digit Verification of cas no
The CAS Registry Mumber 112193-75-6 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,1,2,1,9 and 3 respectively; the second part has 2 digits, 7 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 112193-75:
(8*1)+(7*1)+(6*2)+(5*1)+(4*9)+(3*3)+(2*7)+(1*5)=96
96 % 10 = 6
So 112193-75-6 is a valid CAS Registry Number.
112193-75-6Relevant articles and documents
COMPOSITIONS FOR TARGETED IMAGING AND THERAPY
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Page/Page column 48, (2008/12/04)
The present invention relates to the field of radiochemistry, nuclear imaging, radionuclide therapy and chemical synthesis. More particularly, it concerns a strategy for radiolabeling target ligands. It further concerns methods of using those radiolabeled ligands for imaging, radionuclide therapy and tissue-specific disease imaging.
Process for the preparation of tetraazamacrocycles
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, (2008/06/13)
A process for the preparation of the compounds of formula (I), and (II) comprising the steps represented in the following Scheme, in which the substituents are as defined in the specification. STR1
A General Synthesis of 1,7-Disubstituted 1,4,7,10-Tetraazacyclododecanes
Kovacs, Zoltan,Sherry, A. Dean
, p. 185 - 186 (2007/10/02)
1,4,7,10-Tetraazacyclododecane reacts regioselectively in acid solution with several chloroformates to give 1,7-diprotected derivatives which could be alkylated and deprotected to afford 1,7-disubstituted 1,4,7,10-tetraazacyclododecanes.
