1123-93-9 Usage
Description
1,3-Benzothiazol-5-amine is an organic compound with the chemical formula C7H7NS. It is a heterocyclic compound that consists of a benzene ring fused to a thiazole ring, with an amine group attached to the 5th position. 1,3-BENZOTHIAZOL-5-AMINE is known for its diverse range of applications, particularly in the pharmaceutical industry, due to its unique chemical properties and reactivity.
Uses
Used in Pharmaceutical Industry:
1,3-Benzothiazol-5-amine is used as a pharmaceutical intermediate for the synthesis of various drugs and drug candidates. Its unique structure and reactivity make it a valuable building block in the development of new therapeutic agents.
Used in Allosteric Enhancer Development:
1,3-Benzothiazol-5-amine is used as an allosteric enhancer (AE) of agonist activity at the A1 adenosine receptor. This application is particularly relevant in the development of drugs targeting the central nervous system, as modulation of the A1 adenosine receptor can have therapeutic effects in conditions such as epilepsy, neurodegenerative diseases, and cognitive disorders. By enhancing the activity of agonists at this receptor, 1,3-benzothiazol-5-amine can potentially improve the efficacy and selectivity of these drugs.
Check Digit Verification of cas no
The CAS Registry Mumber 1123-93-9 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 1,1,2 and 3 respectively; the second part has 2 digits, 9 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 1123-93:
(6*1)+(5*1)+(4*2)+(3*3)+(2*9)+(1*3)=49
49 % 10 = 9
So 1123-93-9 is a valid CAS Registry Number.
InChI:InChI=1/C7H6N2S/c8-5-1-2-7-6(3-5)9-4-10-7/h1-4H,8H2
1123-93-9Relevant articles and documents
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Spieler,Prijs
, p. 1429,1431 (1950)
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ACTIVATORS OF THE RETINOIC ACID INDUCIBLE GENE "RIG-I" PATHWAY AND METHODS OF USE THEREOF
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Paragraph 0447-0448, (2020/03/01)
The present invention is directed to compounds of Formula (I), which are activators of the RIG-I pathway.
Visible-Light-Photocatalyzed Reductions of N-Heterocyclic Nitroaryls to Anilines Utilizing Ascorbic Acid Reductant
Todorov, Aleksandar R.,Aikonen, Santeri,Muuronen, Mikko,Helaja, Juho
supporting information, p. 3764 - 3768 (2019/05/24)
A photoreductive protocol utilizing [Ru(bpy)3]2+ photocatalyst, blue light LEDs, and ascorbic acid (AscH2) has been developed to reduce nitro N-heteroaryls to the corresponding anilines. Based on experimental and computational results and previous studies, we propose that the reaction proceeds via proton-coupled electron transfer between AscH2, photocatalyst, and the nitro N-heteroaryl. The method offers a green catalytic procedure to reduce, e.g., 4-/8-nitroquinolines to the corresponding aminoquinolines, substructures present in important antimalarial drugs.
