112378-39-9

Basic information

• Product Name: 2,2-dimethyl-5-(4-nitrobenzoyl)-1,3-dioxane-4,6-dione
• Synonyms: 2,2-dimethyl-5-(4-nitrobenzoyl)-1,3-dioxane-4,6-dione
• CAS NO: 112378-39-9
• Molecular Weight: 293.233
• Mol File: 112378-39-9.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: 2,2-dimethyl-5-(4-nitrobenzoyl)-1,3-dioxane-4,6-dione(CAS DataBase Reference)
• NIST Chemistry Reference: 2,2-dimethyl-5-(4-nitrobenzoyl)-1,3-dioxane-4,6-dione(112378-39-9)
• EPA Substance Registry System: 2,2-dimethyl-5-(4-nitrobenzoyl)-1,3-dioxane-4,6-dione(112378-39-9)

Safety Data

• Hazardous Substances Data: 112378-39-9(Hazardous Substances Data)

Usage

General Description

2,2-dimethyl-5-(4-nitrobenzoyl)-1,3-dioxane-4,6-dione is an organic compound with the molecular formula C13H13NO7. It is a derivative of 1,3-dioxane-4,6-dione that contains a 4-nitrobenzoyl group and two methyl groups attached to the dioxane ring. 2,2-dimethyl-5-(4-nitrobenzoyl)-1,3-dioxane-4,6-dione is often used in organic synthesis and as an intermediate in the production of pharmaceuticals and agrochemicals. It is also known to have antimicrobial and anti-inflammatory properties. The 4-nitrobenzoyl group makes this compound useful for various chemical reactions, including acylation and esterification. Overall, 2,2-dimethyl-5-(4-nitrobenzoyl)-1,3-dioxane-4,6-dione is a versatile chemical with a wide range of potential applications.

Upstream product

• 2033-24-1 cycl-isopropylidene malonate 
• 62-23-7 4-nitro-benzoic acid 
• 122-04-3 4-nitro-benzoyl chloride 

Downstream Products

• 1346441-02-8 N-(4-(1-benzyl-7-oxo-1,6,7,8-tetrahydropyrazolo[3,4-b]-[1,4]diazepin-5-yl)phenyl)-4-chloro-3-(trifluoromethyl)benzamide 
• 1346441-05-1 N-(4-(1-benzyl-7-oxo-1,6,7,8-tetrahydropyrazolo[4,3-b][1,4]diazepin-5-yl)phenyl)-3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)benzamide 
• 1346441-08-4 N-(4-(1-benzyl-7-oxo-1,6,7,8-tetrahydropyrazolo[3,4-b][1,4]diazepin-5-yl)phenyl)-4-morpholino-3-(trifluoromethyl)benzamide 
• 1346441-12-0 1-(4-(1-benzyl-7-oxo-1,6,7,8-tetrahydropyrazolo[3,4-b]-[1,4]diazepin-5-yl)phenyl)-3-(4-chloro-3-(trifluoromethyl)phenyl)urea 
• 1346441-14-2 1-(4-chloro-3-(trifluoromethyl)phenyl)-3-(4-(1-(4-methoxybenzyl)-7-oxo-1,6,7,8-tetrahydropyrazolo[3,4-b][1,4]diazepin-5-yl)phenyl)urea 
• 1346441-18-6 1-(4-(1-benzyl-7-oxo-1,6,7,8-tetrahydropyrazolo[3,4-b]-[1,4]diazepin-5-yl)phenyl)-3-(3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)phenyl)urea 
• 1346441-22-2 1-(4-(1-benzyl-7-oxo-1,6,7,8-tetrahydropyrazolo[3,4-b][1,4]diazepin-5-yl)phenyl)-3-(3-chlorophenyl)urea 
• 1346441-48-2 C₁₉H₁₇N₅O 
• 1346441-54-0 C₂₀H₁₉N₅O₂ 
• 13051-16-6 ethyl 2-methyl-3-(4-nitrophenyl)-3-oxopropanoate 
• 1284376-94-8 C₁₁H₁₁NO₅ 
• 42075-29-6 4-(4-aminophenyl)-3-methyl-4-oxobutanoic acid 
• 838-57-3 ethyl 4-nitrobenzoylacetate 

Relevant articles and documents

Discovery of novel 4-aryl-thieno[1,4]diazepin-2-one derivatives targeting multiple protein kinases as anticancer agents

A series of 4-aryl-thieno[1,4]diazepin-2-one were synthesized and evaluated for their antiproliferative activities against the A375P melanoma and U937 hematopoietic cell lines. Several compounds showed very potent antiproliferative activities toward both cell lines and the activities were better than that of sorafenib, the reference standard. Derivatives were made as amide (8a–8i, 9a–9m) and urea (10a–10d, 11a–11d) with diverse hydrophobic moieties. One of the most potent inhibitor 10d, 1-(4-((4-ethylpiperazin-1-yl)methyl)-3-(trifluoromethyl)phenyl)-3-(4-(2-oxo-2,3-dihydro-1H-thieno [3,4-b][1,4]diazepin-4-yl)phenyl)urea was found to be very potent inhibitor of multi-protein kinases including FMS kinase (IC50 = 3.73 nM) and is a promising candidate for further development in therapeutics for cancer.

A 3-methyl-4-oxo-4 - (P-amino) phenyl-butyric acid

The invention discloses a preparation method of a levosimendan key intermediate 3-methyl-4-oxo-4-(p-amino)phenylbutyric acid, which comprises six reaction steps disclosed in the specification. The method has the advantages of novel technological design, accessible raw materials, environment-friendly reaction conditions, no need of virulent chemicals, high yield of each reaction step, high total yield and safe and simple operation, and is suitable for industrial production.

Microwave assisted rapid and efficient synthesis of aryl methyl ketones and β-keto esters using Meldrum's acid

Microwave mediated rapid and efficient synthesis of aryl methyl ketones and β-keto esters from acyl Meldrum's acid by hydrolysis and alcoholysis, respectively, has been reported.