1126633-49-5

Basic information

• Product Name: 3-(4-(trifluoromethyl)phenyl)isoxazol-5(4H)-one
• Synonyms: 3-(4-(trifluoromethyl)phenyl)isoxazol-5(4H)-one
• CAS NO: 1126633-49-5
• Molecular Weight: 229.158
• Mol File: 1126633-49-5.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: 3-(4-(trifluoromethyl)phenyl)isoxazol-5(4H)-one(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(4-(trifluoromethyl)phenyl)isoxazol-5(4H)-one(1126633-49-5)
• EPA Substance Registry System: 3-(4-(trifluoromethyl)phenyl)isoxazol-5(4H)-one(1126633-49-5)

Safety Data

• Hazardous Substances Data: 1126633-49-5(Hazardous Substances Data)

Upstream product

• 709-63-7 1-(4-trifluoromethylphenyl)ethanone 
• 106263-53-0 ethyl 3-oxo-3-(4-(trifluoromethyl)phenyl)propanoate 
• 1274019-46-3 ethyl 3-hydroxy-3-(4-(trifluoromethyl)phenyl)propanoate 
• 455-19-6 4-Trifluoromethylbenzaldehyde 

Downstream Products

• 1392419-52-1 C₂₂H₁₃ClF₃NO₄ 
• 1327288-28-7 (Z)-4-{4-[4-(trifluoromethoxy)benzyloxy]benzylidene}-3-[4-(trifluoromethyl)phenyl]isoxazol-5(4H)-one 
• 1392419-49-6 C₂₄H₁₄F₃N₅O₃ 
• 1392419-47-4 C₂₄H₁₅F₃N₂O₅ 
• 1327288-02-7 (Z)-4-[4-(2-chlorobenzyloxy)benzylidene]-3-[4-(trifluoromethyl)phenyl]isoxazol-5(4H)-one 
• 1327288-17-4 (Z)-4-[4-(4-chlorobenzyloxy)benzylidene]-3-[4-(trifluoromethyl)phenyl]isoxazol-5(4H)-one 
• 1392419-48-5 C₂₄H₁₆F₃NO₅S 
• 1392419-51-0 C₂₁H₁₂F₃N₃O₂ 
• 1392419-44-1 C₂₄H₁₅ClF₃NO₃ 

Relevant articles and documents

Construction of isoxazolone-fused phenanthridinesviaRh-catalyzed cascade C-H activation/cyclization of 3-arylisoxazolones with cyclic 2-diazo-1,3-diketones

A Rh(iii)-catalyzed cascade C-H activation/intramolecular cyclization of 3-aryl-5-isoxazolones with cyclic 2-diazo-1,3-diketones was described, leading to the formation of isoxazolo[2,3-f]phenanthridine skeletons. The protocol features the simultaneous one-pot formation of two new C-C/C-N bonds and one heterocycle in moderate-to-good yields with good functional group compatibility. It is amenable to large-scale synthesis and further transformation.

Atom-Economic Silver-Catalyzed Difunctionalization of the Isocyano Group with Cyclic Oximes: Towards Pyrimidinediones

An unprecedented silver-catalyzed difunctionalization of the isocyano group with cyclic oximes is described. This method allows efficient and atom-economic assembly of a vast array of structurally novel and interesting pyrimidinediones, and tolerates a range of functionalities. The resulting products can be easily converted into some useful compounds. Furthermore, the method can also be applied for the late-stage modification of a few biologically active molecules.