1274019-46-3

Basic information

• Product Name: ethyl 3-hydroxy-3-(4-(trifluoromethyl)phenyl)propanoate
• Synonyms: ethyl 3-hydroxy-3-(4-(trifluoromethyl)phenyl)propanoate
• CAS NO: 1274019-46-3
• Molecular Weight: 262.229
• Mol File: 1274019-46-3.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: ethyl 3-hydroxy-3-(4-(trifluoromethyl)phenyl)propanoate(CAS DataBase Reference)
• NIST Chemistry Reference: ethyl 3-hydroxy-3-(4-(trifluoromethyl)phenyl)propanoate(1274019-46-3)
• EPA Substance Registry System: ethyl 3-hydroxy-3-(4-(trifluoromethyl)phenyl)propanoate(1274019-46-3)

Safety Data

• Hazardous Substances Data: 1274019-46-3(Hazardous Substances Data)

Upstream product

• 1226784-41-3 ethyl 3-[(4-trifluoromethyl)phenyl]-3-trimethylsiloxypropanoate 
• 455-19-6 4-Trifluoromethylbenzaldehyde 
• 141-78-6 ethyl acetate 
• 4071-88-9 trimethylsilanyl-acetic acid ethyl ester 

Downstream Products

• 106263-53-0 ethyl 3-oxo-3-(4-(trifluoromethyl)phenyl)propanoate 
• 1392419-51-0 C₂₁H₁₂F₃N₃O₂ 
• 1392419-52-1 C₂₂H₁₃ClF₃NO₄ 
• 1392419-47-4 C₂₄H₁₅F₃N₂O₅ 
• 1327288-28-7 (Z)-4-{4-[4-(trifluoromethoxy)benzyloxy]benzylidene}-3-[4-(trifluoromethyl)phenyl]isoxazol-5(4H)-one 
• 1327288-17-4 (Z)-4-[4-(4-chlorobenzyloxy)benzylidene]-3-[4-(trifluoromethyl)phenyl]isoxazol-5(4H)-one 
• 1327288-02-7 (Z)-4-[4-(2-chlorobenzyloxy)benzylidene]-3-[4-(trifluoromethyl)phenyl]isoxazol-5(4H)-one 
• 1126633-49-5 3-(4-(trifluoromethyl)phenyl)isoxazol-5(4H)-one 
• 1392419-48-5 C₂₄H₁₆F₃NO₅S 
• 1392419-49-6 C₂₄H₁₄F₃N₅O₃ 

Relevant articles and documents

One-pot enol silane formation-Mukaiyama aldol reactions: Crossed aldehyde-aldehyde coupling, thioester substrates, and reactions in ester solvents

Trimethylsilyl trifluoromethanesulfonate (TMSOTf) and a trialkylamine base promote both in situ enol silane/silyl ketene acetal formation and Mukaiyama aldol addition reactions between a variety of reaction partners in a single reaction flask. Isolation of the required enol silane or silyl ketene acetal is not necessary. For example, crossed aldol reactions between α-disubstituted aldehydes and non-enolizable aldehydes yield β-hydroxy aldehydes in good yield. In a related reaction, the common laboratory solvent ethyl acetate functions as both an enolate precursor and a green reaction solvent. When thioesters are employed as enolate precursors, high yields for additions to non-enolizable aldehydes are routinely observed.

N-heterocyclic carbene mediated Reformatsky reaction of aldehydes with a-trimethylsilylcarbonyl compounds

N-Heterocyclic carbenes have been employed as highly efficient organocatalysts to mediate silyl-Reformatsky type reaction. In the presence of only 0.5 mol % nucleophilic carbene 1, various aldehydes coupled with α-trimethylsilylethylacetate very smoothly in DMF at room temperature to provide the corresponding β-hydroxyesters in moderate to high yields. α-Trimethylsilylketone and α-trimethylsilylamide can also undergo the addition reaction to give β-hydroxyketone and b-hydroxyamide in moderate yields.