1134188-60-5

Basic information

• Product Name: 5-O-(5-amino-5-deoxy-β-D-ribofuranosyl)-1-N-[(S)-4-amino-2-hydroxy-butanoyl]paromamine
• Synonyms: 5-O-(5-amino-5-deoxy-β-D-ribofuranosyl)-1-N-[(S)-4-amino-2-hydroxy-butanoyl]paromamine
• CAS NO: 1134188-60-5
• Molecular Weight: 555.583
• Mol File: 1134188-60-5.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 5-O-(5-amino-5-deoxy-β-D-ribofuranosyl)-1-N-[(S)-4-amino-2-hydroxy-butanoyl]paromamine(CAS DataBase Reference)
• NIST Chemistry Reference: 5-O-(5-amino-5-deoxy-β-D-ribofuranosyl)-1-N-[(S)-4-amino-2-hydroxy-butanoyl]paromamine(1134188-60-5)
• EPA Substance Registry System: 5-O-(5-amino-5-deoxy-β-D-ribofuranosyl)-1-N-[(S)-4-amino-2-hydroxy-butanoyl]paromamine(1134188-60-5)

Safety Data

• Hazardous Substances Data: 1134188-60-5(Hazardous Substances Data)

Upstream product

• 1134188-65-0 C₂₆H₄₈N₆O₁₅ 
• 1141769-15-4 C₂₁H₃₃N₁₃O₁₂ 

Relevant articles and documents

Novel aminoglycosides and uses thereof in the treatment of genetic disorders

A new class of paromomycin-derived aminoglycosides, which exhibit efficient stop-codon mutation suppression activity, low toxicity and high selectivity towards eukaryotic cells are provided. Also provided are chemical and chemo-enzymatic processes of preparing these paromomycin-derived aminoglycosides and intermediates thereof, as well as pharmaceutical compositions containing the same, and uses thereof in the treatment of genetic disorders.

Combined chemical-enzymatic assembly of aminoglycoside derivatives with N-1-AHB side chain

A series of unprotected pseudo-disaccharides and pseudo-trisaccharides of 2-deoxystreptamine-containing aminoglycosides have been selectively acylated at the N-1 position with the valuable (S)-4-amino-2-hydroxybutanoyl (AHB) pharmacophore by using the recombinant BtrH and BtrG enzymes from butirosin biosynthesis in combination with a synthetic acyl donor. The process was optimized by performing two enzymatic steps in a sequential manner without purification of the intermediate product.