1134188-65-0Relevant articles and documents
Novel aminoglycosides and uses thereof in the treatment of genetic disorders
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Page/Page column 54-56, (2009/04/24)
A new class of paromomycin-derived aminoglycosides, which exhibit efficient stop-codon mutation suppression activity, low toxicity and high selectivity towards eukaryotic cells are provided. Also provided are chemical and chemo-enzymatic processes of preparing these paromomycin-derived aminoglycosides and intermediates thereof, as well as pharmaceutical compositions containing the same, and uses thereof in the treatment of genetic disorders.