1135317-74-6

Basic information

• Product Name: 1-(3,5-di-tert-butylphenyl)-2-(2-(3-hydroxypropylamino)-5,6-dimethyl-1H-benzo[d]imidazol-1-yl)ethanone
• CAS NO: 1135317-74-6
• Molecular Weight: 449.637
• Mol File: 1135317-74-6.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 1-(3,5-di-tert-butylphenyl)-2-(2-(3-hydroxypropylamino)-5,6-dimethyl-1H-benzo[d]imidazol-1-yl)ethanone(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(3,5-di-tert-butylphenyl)-2-(2-(3-hydroxypropylamino)-5,6-dimethyl-1H-benzo[d]imidazol-1-yl)ethanone(1135317-74-6)
• EPA Substance Registry System: 1-(3,5-di-tert-butylphenyl)-2-(2-(3-hydroxypropylamino)-5,6-dimethyl-1H-benzo[d]imidazol-1-yl)ethanone(1135317-74-6)

Safety Data

• Hazardous Substances Data: 1135317-74-6(Hazardous Substances Data)

Upstream product

• 717915-17-8 2,6-di-tert-butylbromoacetophenone 
• 301163-47-3 3-((5,6-dimethyl-1H-benzo[d]imidazol-2-yl)amino)propan-1-ol 

Relevant articles and documents

Inhibition of protein kinase C-driven nuclear factor-κB activation: Synthesis, structure-activity relationship, and pharmacological profiling of pathway specific benzimidazole probe molecules

A unique series of biologically active chemical probes that selectively inhibit NF-κB activation induced by protein kinase C (PKC) pathway activators have been identified through a cell-based phenotypic reporter gene assay. These 2-aminobenzimidazoles represent initial chemical tools to be used in gaining further understanding on the cellular mechanisms driven by B and T cell antigen receptors. Starting from the founding member of this chemical series 1a (notated in PubChem as CID-2858522), we report the chemical synthesis, SAR studies, and pharmacological profiling of this pathway-selective inhibitor of NF-κB activation.